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The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization

  • Andrew N. Antoszyk
  • Justin L. Gottlieb
  • Robert Machemer
  • Diane L. Hatchell
Laboratory Investigations

Abstract

Corticosteroids, alone or in combination with other drugs, have been shown to inhibit angiogenesis. The purpose of this study was to evaluate the efficacy of triamcinolone acetonide in a new model of preretinal neovascularization. Rabbit eyes were treated with intravitreal triamcinolone acetonide 24 h before partial liquefaction of the posterior vitreous with hyaluronidase and injection of 250000 homologous tissue-cultured dermal fibroblasts. Triamcinolone acetonide effectively inhibited new vessel growth in treated eyes. Only 14% of the treated eyes developed new blood vessels compared to 100% of sham-injected control eyes (P<0.001). These results suggest that intravitreal triamcinolone acetonide might be effective in inhibiting new vessel growth in patients with inflammatory retinal neovascularization, such as that associated with sarcoidosis or other uveitic syndromes.

Keywords

Public Health Corticosteroid Blood Vessel Liquefaction Sarcoidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Andrew N. Antoszyk
    • 1
    • 4
  • Justin L. Gottlieb
    • 2
  • Robert Machemer
    • 1
  • Diane L. Hatchell
    • 1
    • 2
    • 3
  1. 1.Department of OphthalmologyDuke UniversityUSA
  2. 2.Department of Cell BiologyDuke UniversityUSA
  3. 3.the Durham Veterans Affairs Medical CenterDurhamUSA
  4. 4.Department of SurgeryUniformed Services University of the Health SciencesBethesdaUSA

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