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Inflammation Research

, Volume 44, Supplement 1, pp S90–S91 | Cite as

A steric approach for the design of antihistamines with low muscarinic receptor antagonism

  • M. -Q. Zhang
  • K. Walczynski
  • H. Timmerman
5. Histamine metabolism, receptors and antihistamines

Keywords

Muscarinic Receptor Receptor Antagonism Muscarinic Receptor Antagonism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Remy DC, Rittle KE, Hunt CA, Anderson PS, Engelhardt EL, Clineschmidt BV et al. (+)- and (−)-3-Methoxycyproheptadine: a comparative evaluation of the antiserotonin, antihistaminic, anticholinergic, and orexigenic properties with cyproheptadine. J Med Chem 1977;20:1681–4.Google Scholar
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    Zhang M-Q, Ter Laak AM, Timmerman H. Structure-activity relationships within a series of analogues of the histamine H1-antagonist terfenadine. Eur J Med Chem 1993;28:165–73.Google Scholar
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    Eglen RM, Reddy H, Watson N, Challiss RAJ. Muscarinic acetylcholine receptor subtypes in smooth muscle. Trends Pharmacol Sci 1994;15:114–9.Google Scholar
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    Polymeropoulos EE, Kutscher B, Fleischhauer I. Computerassisted analysis of the possible binding sites of H1-antagonists. In QSAR: Rational Approaches to the Design of Bioactive Compounds. (Ed. Silipo C and Vittoria A) pp. 261–264, Elsevier Science Publishers B.V., Amsterdam 1991.Google Scholar

Copyright information

© Birkhäuser Verlag 1995

Authors and Affiliations

  • M. -Q. Zhang
    • 1
  • K. Walczynski
    • 1
  • H. Timmerman
    • 1
  1. 1.Leiden/Amsterdam Center for Drug ResearchDivision of Medicinal Chemistry, Vrije UniversiteitAmsterdamThe Netherlands

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