Phospholipoide in Hirntumoren
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Zusammenfassung
In Hirntumoren und tumorfreien Hirngeweben von Mensch und Kaninchen wurden verschiedene Phospholipoid-Fraktionen bestimmt. Die statistische Auswertung ergab für Tumoren eine signifikante Senkung aller absoluten Parameter. Der Quotient aus den nach alkalischer Hydrolyse erhaltenen cholinhaltigen und cholinfreien Fraktionen ist in den Hirntumoren signifikant erhöht. Unterschiede im Phospholipoidgehalt zwischen malignen und benignen Hirntumoren waren statistisch nicht erfaßbar.
Summary
Various phospholipoid fractions were estimated in brain tumours an in normal human and rabbit brain tissue. A statistical evaluation showed a significant diminution of all absolute values in brain tumours. The ratio of choline-containing to choline-free fractions, measured after alkaline hydrolysis, is significantly higher in brain tumours. No statistically significant differences were noted in the phospholipoid contents of malignant and benign brain tumours.
Résumé
Les auteurs ont étudié la présence de différentes fractions phospholipidiques dans les tumeurs du cerveau et le tissu cérébral non tumoral de l'homme et du lapin. Les évaluations statistiques mettent en évidence pour les tumeurs une baisse significative de tous les paramètres absolus. La proportion entre les fractions contenant de la choline et les fractions n'en contenant pas, après hydrolyse alcaline, est augmentée de façon significative dans les tumeurs cérébrales. Par contre, une différence de teneur en phospholipides entre tumeurs malignes et tumeurs bénignes, n'a pu être statistiquement mise en évidence.
Riassunto
Gli AA. hanno deterrninato le varie frazioni di fosfolipidi in tumori cerebrali ed in tessuti cerebrali esenti da tumori dell'uomo e del coniglio.
L'elaborazione statistica dà per i tumori un significativo abbassamento di tutti i parametri assoluti. Il quoziente ricavato dalle frazioni a contenuto colinico e da quelle esenti da colina, in seguito ad idrolisi alcalina, risulta significativamente aumentato nei tumori.
Non è stato possibile rilevare delle differenze statisticamente significative del contenuto di fosfolipidi tra tumori cerebrali maligni e benigni.
Resumen
En tumores cerebrales y en tejido cerebral no tumoral humano y de conejo se analizaron diversas fracciones de fosfolípidos. La valoración estadística dió por resultado, para los tumores, una disminución significante de todos los parámetros absolutos. El cociente de las fracciones conteniendo colina y libres de la misma, tras la hidrólisis alcalina, está significantemente aumentado en el caso de tumores cerebrales. Estadisticamente no se apreciaron diferencias entre el contenido de fosfolípidos en los tumores cerebrales malignos y benignos.
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