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The structure of ethyl allyl 1,4-dihydro-2,6-dimethyl-4-[4-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-3,5-pyridine dicarboxylate


The crystal and molecular structure of the title compound has been determined by direct methods, and refined to a finalR of 0.070 for 1466 observed reflections. The compound crystallizes in space group P2l/n with cell dimensionsa=10.706(8),b=21.127(11),c=12.038(10) Å, Z=4.1,4-dihydropyridine ring adopts a boat shaped conformation. The flavon molecule is planar and it's phenyl ring is almost perpendicular to the 1,4-DHP. The C36 atom of the allyl group shows disorder.

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  1. 1.

    Hirakawa, S.; Ito, H.; Kondo, Y.; Watanabe, I.; Hiei, K.; Banno, S.; Hayase, S.Arzneim.-Forsch./Drug Res. 1972,22(2), 344.

  2. 2.

    Nayler, W. G.Calcium Antagonists: Academic Press; New York, 1988.

  3. 3.

    Rampa, A.; Chiarini, A.; Bisi, A.; Budriesi, R.; Valenti, P.Arzneim-Forsch/Drug. Res. 1991,41(11), 705.

  4. 4.

    Hantzsch, A.Justus Liebig's Ann. Chem. 1882,215, 1.

  5. 5.

    Sheldrick, G. M.SHELXTL PC Release 4.1: Siemens Crystallographic Research Systems; Madison, WI, 1990.

  6. 6.

    Natale, N. R.; Triggle, D. J.; Palmer, R. B.; Lefler, B. J.; Edwards, W. D.J. Med. Chem. 1990,33, 2255.

  7. 7.

    Schauer, C. K.; Anderson, O. P.; Natale, N. R.; Quincy, D. A.Acta Cryst. 1986,C42, 884.

  8. 8.

    Triggle, A. M.; Shefter, Ė; Triggle, D. J.J. Med. Chem. 1980,23, 1442.

  9. 9.

    Fossheim, R.; Svarteng, K.; Mostad, A.; Romming, C.; Shefter, E.; Triggle, D. J.J. Med. Chem. 1982,25, 126.

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Kendi, E., Özbey, S., Tunçbilek, M. et al. The structure of ethyl allyl 1,4-dihydro-2,6-dimethyl-4-[4-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-3,5-pyridine dicarboxylate. J Chem Crystallogr 24, 747–751 (1994).

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Key Words

  • 1,4-DHP
  • calcium antagonistic activity
  • nifedipine