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Palliative therapy of an ectopic cushing's syndrome due to a metastatic carcinoid tumor

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Summary

The case of a 39-year-old patient with ectopic Cushing's syndrome due to a metastatic carcinoid tumor is presented. Palliative therapy consisting of 800 mg ketokonazole and 0.3 mg SMS 201-995/die resulted in clinical remission and correction of hypokaelmia and hypercortisoluria. Combined therapy was clearly superior to monotherapy with ketokonazole or SMS 201-995, respectively. Side effects were not observed, the tumor masses remained unchanged throughout the observation period of now 19 months.

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Abbreviations

ACTH:

adrenocorticotropic hormone

o′p′DDD:

1,1 dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)-ethane

5-HIAA:

5-hydroxyindolaceticacid

VIP:

vasoactive intestinal pepide

CRH:

corticotropin releasing hormone

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Kornely, E., Schlaghecke, R. & Horster, F.A. Palliative therapy of an ectopic cushing's syndrome due to a metastatic carcinoid tumor. Klin Wochenschr 69, 173–176 (1991). https://doi.org/10.1007/BF01665863

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Key words

  • Ectopic Cushing's syndrome
  • Ketokonazole
  • SMS 201-995
  • Carcinoid tumor
  • Palliative therapy