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Ofloxacin, a new quinolone in the treatment of genitourinary and enteric infections

Ofloxacin, ein neues Chinolon in der Therapie urogenitaler und intestinaler Infektionen

Summary

During 1984 to 1986, 121 patients with gonorrhoea were treated with ofloxacin. This report is to summarize the results of our trial in patients treated with three different dose regimens of ofloxacin: A) a single 800 mg dose of ofloxacin (32 patients); B) a single 400 mg dose of ofloxacin (55 patients) or C) a twice a day dose of 600 mg ofloxacin (34 patients). In addition, 19 patients with urinary tract infection and eight patients with enteric fever were treated with 400 mg ofloxacin twice a day for seven to ten days. Out of 121 patients with gonococcal urethritis, only 107 patients were evaluable. Cure was obtained in 96.5%; 93.2% and 94.5% of the patients in groups A, B and C respectively. 16 out of 17 patients with urinary tract infection achieved clinical cure or improvement. The 16 patients were bacteriologically assessible; pathogens were eradicated in all of them. Ofloxacin was also effective in the treatment of enteric fever, in which eradication was achieved in all seven patients. 28% ofNeisseria gonorrhoea and 29% ofSalmonella spp. isolated in our community were β-lactamase-positive.

Zusammenfassung

Von 1984 bis 1986 wurden 121 an Gonorrhoe erkrankte Patienten mit Ofloxacin behandelt. Die Ergebnisse unserer mit drei verschiedenen Ofloxacindosierungen durchgeführten Studie werden im folgenden mitgeteilt. Dosierung A: Einzeldosis von 800 mg Ofloxacin (32 Patienten); Dosierung B: Einzeldosis von 400 mg Ofloxacin (55 Patienten); Dosierung C: 600 mg Ofloxacin zweimal täglich (34 Patienten). Außerdem wurden 19 Patienten mit Harnwegsinfektionen und acht Patienten mit Typhus für sieben bis zehn Tage mit 400 mg Ofloxacin zweimal täglich behandelt. Von den 121 Patienten mit Gonokokken-Urethritis konnten nur 105 ausgewertet werden. Bei 96,5% der Gruppe A, 93,2% der Gruppe B und 94,5% der Gruppe C wurde eine Heilung erzielt. 16 der 17 Patienten mit Harnwegsinfektionen wurden geheilt oder gebessert. Eine bakteriologische Kontrolluntersuchung bei 16 dieser Patienten ergab eine Eradikationsrate von 100%. Ofloxacin erwies sich auch als wirksam in der Typhustherapie. Bei allen sieben behandelten Patienten wurden die Erreger eliminiert. 28% der in unserem Krankengut isoliertenN. gonorrhoeae-Stämme und 29% derSalmonella spp. waren β-laktamasepositiv.

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Tanphaichitra, D., Sahaphong, S. & Srimuang, S. Ofloxacin, a new quinolone in the treatment of genitourinary and enteric infections. Infection 14, S321–S323 (1986). https://doi.org/10.1007/BF01661308

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Keywords

  • Internal Medicine
  • Infectious Disease
  • General Practice
  • Urinary Tract Infection
  • Family Medicine