, Volume 13, Issue 2, pp 82–84 | Cite as

Comparison of the development of experimental pyelonephritis in homozygous brattleboro diabetes insipidus rats, heterozygous control rats and normal wistar rats

  • M. Güngör
  • H. Sagduyu
  • H. Koyuncuoglu
  • Ö. Ang
  • V. Uysal
  • D. Inanç
  • M. Ang


A comparative study was performed on haematogenous experimental pyelonephritis by injecting aStaphylococcus aureus suspension i.v. to homozygous and heterozygous Brattleboro and Wistar rats. The numbers of viable bacteria in blood, urine and kidney homogenates and the pathomorphological scores determined on the tenth day of infection were significantly lower in Brattleboro diabetes insipidus rats than in heterozygous Brattleboro and normal Wistar rats. The results suggest that homozygous Brattleboro rats are much more resistant to experimental pyelonephritis.


Vasopressin Oxytocin Pyelonephritis Diabetes Insipidus Kidney Homogenate 
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Vergleich der Entwicklung einer experimentellen Pyelonephritis bei homozygoten Brattleboro-Ratten mit Diabetes insipidus, heterozygoten Kontrolltieren und normalen Wistar-Ratten


Die Entwicklung einer hämatogenen experimentellen Pyelonephritis nach i.v. Injektion einerStaphylococcus aureus-Suspension wurde bei homozygoten und heterozygoten Brattleboro-Ratten und Wistar-Ratten in einer Vergleichsstudie geprüft. Am zehnten Tag der Infektion wurde die Zahl lebender Bakterien im Blut, Urin und in Nierenhomogenaten untersucht und eine morphologische Graduierung durchgeführt; dabei waren die Bakterienzahlen und morphologischen Veränderungen bei Brattleboro-Ratten mit Diabetes insipidus signifikant geringfügiger als bei heterozygoten Brattleboro-Ratten und bei Wistar-Ratten. Daraus läßt sich schließen, daß homozygote Brattleboro-Ratten gegen eine experimentelle Pyelonephritis wesentlich resistenter sind als die übrigen geprüften Tierstämme.


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Copyright information

© MMV Medizin Verlag GmbH München 1985

Authors and Affiliations

  • M. Güngör
    • 1
  • H. Sagduyu
    • 1
  • H. Koyuncuoglu
    • 1
  • Ö. Ang
    • 2
  • V. Uysal
    • 3
  • D. Inanç
    • 4
  • M. Ang
    • 4
  1. 1.Department of PharmacologyIstanbul Medical Faculty, ÇapaIstanbulTurkey
  2. 2.Department of MicrobiologyIstanbul Medical Faculty, ÇapaIstanbulTurkey
  3. 3.Department of PathologyIstanbul Medical Faculty, ÇapaIstanbulTurkey
  4. 4.Department of MicrobiologyIstanbul Faculty of DentistryIstanbulTurkey

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