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Effect of endogenous secretin on plasma glucagon after total pancreatectomy


Normal dogs and totally pancreatectomized dogs with intact stomach and duodenum were given 0.1 N hydrochloric acid directly into the duodenum in a study of the effect of endogenous secretin on glucagon secretion. The glucagon responsive to 30K antibody first decreased after total pancreatectomy, but increased with time if no insulin was administered. Total pancreatectomy was followed by a gradual, statistically significant increase in the basal secretion of blood secretin. The endogenous secretin secreted in response to the infusion of 0.1 N hydrochloric acid into the duodenum in no way varied the blood glucagon level in normal dogs, but slightly decreased blood gut glucagon in totally pancreatectomized dogs. The secretion of blood secretin in response to the infusion of 0.1 N hydrochloric acid into the duodenum was maintained even after total pancreatectomy.

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Correspondence to Takaaki Sudo M.D..

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Sudo, T., Suzuki, T., Tobe, T. et al. Effect of endogenous secretin on plasma glucagon after total pancreatectomy. World J. Surg. 5, 839–844 (1981).

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  • Hydrochloric Acid
  • Glucagon
  • Secretin
  • Glucagon Secretion
  • Total Pancreatectomy