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Journal of Molecular Evolution

, Volume 2, Issue 4, pp 303–316 | Cite as

Catalysts for the self-polymerization of adenosine cyclic 2′,3′-phosphate

  • M. S. Verlander
  • R. Lohrmann
  • L. E. Orgel
Article

Summary

When adenosine cyclic 2′,3′-phosphate is evaporated from solution in the presence of simple catalysts such as aliphatic diamines at alkaline pH, and maintained in a dry state at moderate temperatures (25-85°C), self-polymerization to give oligonucleotides of chainlength up to at least 6 is observed. The products contain an excess of [3′→5′]-linkages over [2′→5′]-linkages. The effects of different catalysts and reaction conditions on the efficiency of the reaction are described. The prebiological relevance of these reactions is discussed.

Key words

Polymerization Phosphorylation Adenosine Cyclic 2′,3′-phosphate Oligonucleotides Amines 2-Aminoethanol Amino Acids Prebiotic 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • M. S. Verlander
    • 1
    • 2
  • R. Lohrmann
    • 1
  • L. E. Orgel
    • 1
  1. 1.The Salk Institute for Biological StudiesSan DiegoUSA
  2. 2.Department of ChemistryUniversity of CaliforniaLa JollaSan DiegoUSA

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