Journal of Molecular Evolution

, Volume 2, Issue 4, pp 303–316 | Cite as

Catalysts for the self-polymerization of adenosine cyclic 2′,3′-phosphate

  • M. S. Verlander
  • R. Lohrmann
  • L. E. Orgel


When adenosine cyclic 2′,3′-phosphate is evaporated from solution in the presence of simple catalysts such as aliphatic diamines at alkaline pH, and maintained in a dry state at moderate temperatures (25-85°C), self-polymerization to give oligonucleotides of chainlength up to at least 6 is observed. The products contain an excess of [3′→5′]-linkages over [2′→5′]-linkages. The effects of different catalysts and reaction conditions on the efficiency of the reaction are described. The prebiological relevance of these reactions is discussed.

Key words

Polymerization Phosphorylation Adenosine Cyclic 2′,3′-phosphate Oligonucleotides Amines 2-Aminoethanol Amino Acids Prebiotic 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Biebricher, C. K.: Biochim. biophys. Acta (Amst.) (1973), in pressGoogle Scholar
  2. Chang, J. H.: Ground Temperature I. Harvard University, Blue Hill Meteorological Observatory, June 1958Google Scholar
  3. Ibanez, J. D., Kimball, A. P., Oro, J.: In: Chemical evolution and the origin of life, R. Buvet, C. Ponnamperuma, ed., p. 171. Amsterdam: North-Holland 1971Google Scholar
  4. Ibanez, J. D., Kimball, A. P., Oro, J.: J. molec. Evolution1, 112 (1972)Google Scholar
  5. Khoury, S.: M. S. Thesis, California State University, San Diego, 1971Google Scholar
  6. Lohrmann, R., Orgel, L. E.: Science171, 490 (1971)Google Scholar
  7. Markham, R.: In: Methods in enzymology, III, S. P. Colowick and N. O. Kaplan, eds., p. 809, New York: Academic Press 1957Google Scholar
  8. Moravek, J., Kopecky, J., Skoda, J.: Coll. Czech. Chem. Comm.33, 960 (1968)Google Scholar
  9. Moravek, J., Skoda, J.: Coll. Czech. Chem. Comm.32, 206 (1967)Google Scholar
  10. Österberg, R., Lohrmann, R., Orgel, L. E.: J. molec. Evolution2, 231 (1973)Google Scholar
  11. Renz, M., Lohrmann, R., Orgel, L. E.: Biochim. biophys. Acta240, 463 (1971)Google Scholar
  12. Roberts, G. C. K., Dennis, E. A., Meadows, D. H., Cohen, J. S., Jardetzky, O.: Proc. nat. Acad. Sci. (Wash.)62, 1151 (1969)Google Scholar
  13. Sanchez, R. A., Fuller, W. D.: Unpublished observations, Death Valley, California, August 1971Google Scholar
  14. Skoda, J., Moravek, J., Kopecky, J.: Sixth FEBS Meeting Abstr. 433 (1969)Google Scholar
  15. Smith, M., Moffat, J. G., Khorana, H. G.: J. Amer. chem. Soc.80, 6204 (1958)Google Scholar
  16. Tapiero, C. M., Nagyvary, J.: Nature (Lond.)231, 42 (1971)Google Scholar

Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • M. S. Verlander
    • 1
    • 2
  • R. Lohrmann
    • 1
  • L. E. Orgel
    • 1
  1. 1.The Salk Institute for Biological StudiesSan DiegoUSA
  2. 2.Department of ChemistryUniversity of CaliforniaLa JollaSan DiegoUSA

Personalised recommendations