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Further studies of urea-catalyzed phosphorylation reactions

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We have analyzed the products formed when mixtures of a nucleoside and ammonium dihydrogen phosphate are heated with an excess of urea. If there is more phosphate than nucleoside in the mixture, compounds containing pyrophosphate bonds are obtained. If uridine, as nucleoside, is in excess over phosphate, di- and oligonucleotides are formed.

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  1. Lohrmann, R., Orgel, L. E.: Science171, 490 (1971).

  2. Moravek, J., Skoda, J.: Coll. Czech. Chem. Commun.32, 206 (1967).

  3. Österberg, R., Orgel, L. E.: J. molec. Evolution1, 241 (1972).

  4. Pfitzner, K. E., Moffatt, J. G.: J. Org. Chem.29, 1508 (1964).

  5. Ponnamperuma, C., Mack, R.: Science148, 1221 (1965).

  6. Sulston, J., Lohrmann, R., Orgel, L. E., Miles, H. T.: Proc. nat. Acad. Sci. (Wash.)59, 726 (1968).

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On leave from Department of Medical Biochemistry, University of Göteborg, Sweden.

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Österberg, R., Orgel, L.E. & Lohrmann, R. Further studies of urea-catalyzed phosphorylation reactions. J Mol Evol 2, 231–234 (1973).

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Key words

  • Phosphorylation
  • Nucleotides
  • Nucleoside Polyphosphates
  • Oligonucleotides
  • Urea
  • Prebiotic