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Azathioprine treatment in a patient with HBsAg-positive acute viral hepatitis complicated by bridging necrosis

Azathioprin-Behandlung eines Patienten mit HBsAg-positiver akuter Virus-Hepatitis, komplizien durch Brückennekrosen

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Summary

A patient with HBsAg-positive subacute hepatitis who presented a progressively deteriorating clinical condition was treated with azathioprine (100 mg/day) for eight months. Although the clinical symptoms disappeared and the biochemical abnormalities decreased, the disease nevertheless progressed to chronic active hepatitis. Moreover, azathioprine favoured hepatitis B virus replication since titers of HBsAg, HBeAg and Dane-particle-associated coreantigen, as detected by radioimmunoassay, increased during treatment. In all, this drug was only of moderate use to our patient.

Zusammenfassung

Ein Patient mit HBsAg-positiver, subakuter Hepatitis und progressiver klinischer Verschlechterung wurde acht Monate lang mit 100 mg/Tag Azathioprin behandelt. Obwohl die klinischen Symptome verschwanden und sich die biochemischen Parameter besserten, ging die Erkrankung in eine chronisch aktive Hepatitis über. Daneben begünstigte Azathioprin die Hepatitis-B-Virus-Replikation, denn die im Radioimmunoassay bestimmten Titer von HBsAg, HBeAg und Dane-Partikel-assoziiertem Core Antigen stiegen unter der Behandlung an. Insgesamt war das Medikament nur von mäßigem Nutzen für den Patienten.

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Sagnelli, F., Felaco, F.M., Pasquale, G. et al. Azathioprine treatment in a patient with HBsAg-positive acute viral hepatitis complicated by bridging necrosis. Infection 11, 31–32 (1983). https://doi.org/10.1007/BF01651354

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Keywords

  • Hepatitis
  • General Practice
  • Family Medicine
  • Virus Replication
  • Viral Hepatitis