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Virus-associated haemophagocytic syndrome with Epstein-Barr virus infection

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Summary

The clinical and histological findings of a 10-year-old girl with virus-associated haemophagocytic syndrome are presented. The serum levels of Epstein-Barr viral antigens were elevated. Epstein-Barr virus (EBV) genome was detected by polymerase chain reaction in bone marrow and lymph node specimens. Histologically, haemophagocytic histiocytes were present in bone marrow, and areas of non-suppurative necrosis were present in lymph nodes, where silver grain deposition of the EBV genome was demonstrated by in situ hybridization.

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Correspondence to Kohichi Ohshima.

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Ohshima, K., Kikuchi, M., Eguchi, F. et al. Virus-associated haemophagocytic syndrome with Epstein-Barr virus infection. Vichows Archiv A Pathol Anat 419, 519–522 (1991). https://doi.org/10.1007/BF01650682

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Key words

  • Virus-associated haemophagocytic syndrome
  • Epstein-Barr virus
  • In situ
  • Polymerase chain reaction