International Journal of Colorectal Disease

, Volume 2, Issue 4, pp 208–213 | Cite as

Submucosal collagen changes in the normal colon and in diverticular disease

  • H. J. Thomson
  • A. Busuttil
  • M. A. Eastwood
  • A. N. Smith
  • R. A. Elton
Original Articles


Full thickness specimens of normal colon (n=15), and colon from patients with diverticular disease (n = 5) were obtained at operation or autopsy. In the isolated submucosa the ultrastructure of the constituent collagen fibres was examined by transmission electron microscopy. Collagen fibrils in the left colon become smaller (p < 0.001) and more tightly packed (p< 0.001) than those in the right colon with increasing age. This difference is accentuated in diverticular disease (p<0.01). Factors which contribute to the development of colonic diverticulosis, such as raised intraluminal pressure, may be responsible for premature change in submucosal structure.


Collagen Electron Microscopy Transmission Electron Microscopy Internal Medicine Fibril 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Smith AN (1986) Colonic muscle in diverticular disease. In: Mendeloff AI (ed) Pathophysiology of non-neoplastic colonic disorders, Vol 15. Saunders, London pp 917–936Google Scholar
  2. 2.
    Weinreich J, Andersen D (1976) Intraluminal pressure in the sigmoid colon. II. Patients with sigmoid diverticula and related conditions. Scand J Gastroenterol 11:581–586Google Scholar
  3. 3.
    Painter NS (1975) Diverticular disease of the colon. Heinemann, LondonGoogle Scholar
  4. 4.
    Whiteway J, Morson BC (1985) Pathology of the ageing — diverticular disease. Clin Gastroenterol 14:829–846Google Scholar
  5. 5.
    Halsted WS (1891) Intestinal anastomosis. Bull Johns Hopkins Hosp II:1–4Google Scholar
  6. 6.
    Watters DA, Smith AN, Eastwood MA, Anderson KC, Elton RA, Mugerwa JW (1985) Mechanical properties of the colon: comparison of the features of the African and European colon in vitro. Gut 26:384–392Google Scholar
  7. 7.
    Watters DA (1983) The mechanical properties of the bowel in health and disease. Ch.M. thesis, University of EdinburghGoogle Scholar
  8. 8.
    Lord MG, Valies O (1977) A morphologic study of the submucosa of the large intestine. Surg Gynecol Obstet 145:55–60Google Scholar
  9. 9.
    De Carvalho CA (1973) Contribution to the functional study of tubular viscera. Arq Gastroenterol 10:183–190Google Scholar
  10. 10.
    Thomson HJ, Busuttil A, Eastwood MA, Smith AN, Elton RA (1987) The submucosa of the human colon. J Ultrastruct Res 96:22–30Google Scholar
  11. 11.
    Klein L, Eichelberger H, Mirian M, Hiltner A (1983) Ultrastructural properties of collagen fibrils in rat intestine. Connect Tissue Res 12:71–78Google Scholar
  12. 12.
    Parry DA, Barnes GR, Craig AS (1978) A comparison of the size distribution of collagen fibrils in connective tissue as a function of age and a possible relation between fibril size distribution and mechanical properties. Proc R Soc Lond 203:305–321Google Scholar
  13. 13.
    Flint MH, Craig AS, Reilly HC, Gillard GC, Parry DA (1984) Collagen fibril diameters and glycosaminoglycan content of skins — indices of tissue maturity and function. Connect Tissue Res 13:69–81Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • H. J. Thomson
    • 1
  • A. Busuttil
    • 2
  • M. A. Eastwood
    • 1
  • A. N. Smith
    • 1
  • R. A. Elton
    • 3
  1. 1.Gastrointestinal UnitWestern General HospitalEdinburghScotland
  2. 2.Pathology DepartmentWestern General HospitalEdinburghScotland
  3. 3.Medical Statistics UnitUniversity of EdinburghEdinburghScotland

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