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Klinische Wochenschrift

, Volume 69, Issue 13, pp 536–551 | Cite as

New horizons in renal vasculitis

  • J. S. Cameron
Article

Summary

After a long period during which few new data on the vasculitides emerged, the past decade has seen a real explosion of data on the subject. This began with basic clinical descriptions and the deliniation of long term outcome as survival improved to a major extent under the influence of improved treatment regimes. In parallel, better understanding of the immunopathology has emerged. Of particular interest have been descriptions of autoantibody systems in vasculitis which seem to be specific to vasculitis and therefore diagnostically useful: the antineutrophil cytoplasmic antibodies (ANCA). Whether or not these are pathogenetically significant as well as useful remains a matter for debate. In parallel, anti endothelial cell antibodies have been described, but their role (if any), in pathogenesis remains equally obscure. There are some suggestions that vasculitis is becoming more common, but increased awareness and the availability of ANCA have undoubtedly increased awareness of the subject.

Key words

Vasculitis Polyarteritis Wegener's granuloma Anti-neutrophil Cytoplasmic antibody (ANCA) Schonlein-Henoch purpura Glomerulonephritis 

Abbreviations

AECA

anti endothelial cell antibodies

ACR

American College of Rheumatology

ANCA

anti neutophil cytoplasmic antibodies

DNA

deoxyribonucleic acid

ESR

erythrocyte sedimentation rate

HLA

human leukocyte antigen

NSAID

non steroidal anti-inflammatory drug

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • J. S. Cameron
    • 1
    • 2
  1. 1.United Medical and Dental Schools of Guy's and St Thomas's HospitalsLondonUK
  2. 2.Clinical Science LaboratoriesGuy's HospitalLondonUK

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