Klinische Wochenschrift

, Volume 69, Issue 12, pp 527–534

The prevalence of homocysteinemia and hypercholesterolemia in angiographically defined coronary heart disease

  • J. B. Ubbink
  • W. J. H. Vermaak
  • J. M. Bennett
  • P. J. Becker
  • D. A. van Staden
  • S. Bissbort
Originals

DOI: 10.1007/BF01649290

Cite this article as:
Ubbink, J.B., Vermaak, W.J.H., Bennett, J.M. et al. Klin Wochenschr (1991) 69: 527. doi:10.1007/BF01649290

Summary

Total serum homocysteine and cholesterol levels were determined in 163 male patients with typical angina who were subjected to coronary angiography. The prevalence of homocysteinemia in coronary heart disease (CHD) was 41.9%. Serum homocysteine levels were significantly elevated (p<0.05) in patients with major occlusion in two or three coronary arteries. Furthermore, the prevalence of homocysteinemia correlated positively (p<0.05) with the number of coronary vessels that were occluded. The prevalence of hypercholesterolemia was 34.9%, but, in contrast to homocysteinemia, no graded strength of association with the number of stenotic coronary arteries could be demonstrated. The results suggest that homocysteinemia may contribute significantly to the development of coronary heart disease.

Key words

Homocysteine Cholesterol Coronary heart disease Prevalence Folic acid Vitamin B6 Vitamin B12 Venda 

Abbreviations

CHD

coronary heart disease

HPLC

highperformance liquid chromatography

MTHF

methylenetetrahydrofolate

SD

standard deviation

SBD-F

ammonium 7-fluoro 2-oxa-1,3 diazole-4-sulphonate

TC

total cholesterol

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • J. B. Ubbink
    • 1
  • W. J. H. Vermaak
    • 1
  • J. M. Bennett
    • 2
  • P. J. Becker
    • 3
  • D. A. van Staden
    • 1
  • S. Bissbort
    • 1
  1. 1.Department of Chemical Pathology and the Hans Snyckers Institute, Faculty of MedicineUniversity of PretoriaSouth Africa
  2. 2.Department of Cardiology, Faculty of MedicineUniversity of PretoriaSouth Africa
  3. 3.Institute for BiostatisticsMedical Research CouncilPretoria

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