D-ribose was given orally and/or intravenously to nine healthy subjects at doses ranging from 83.3 to 222.2 mg/kg per hour for at least four hours. The serum ribose level increased in a dose-dependent manner to maximum concentrations of 75 to 85 mg/dl. The serum glucose level decreased after the beginning of continuous ribose administration and was reduced as long as ribose was being administered. The oral or intravenous administration of 166.7 mg/kg per hour of ribose resulted in a 25% decrease in serum glucose. Higher intravenous doses of ribose did not provoke a further decrease in serum glucose concentration. Oral administration of 166.7 mg/kg per hour led to an increase in serum insulin concentrations from a mean of 8.4 (range 6.4–11.5) to 10.4 (range 6.3–15.4) μU/ml (p<0.05). In contrast, intravenous administration did not change serum insulin concentrations significantly. The serum c-peptide concentration remained unchanged regardless of treatment. We conclude that the variations in plasma insulin concentrations do not account for the observed decrease in mean serum glucose concentrations accompanying D-ribose administration.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Ginsburg J, Boucher B, Beaconsfield P (1970) Hormonal changes during ribose-induced hypoglycemia. Diabetes 19:23–27
Goetz FC, Maney JW, Greenberg BZ (1967) The regulation of insulin secretion: effects of the infusion of glucose, ribose, and other sugars into the portal veins of dogs. J Lab Clin Med 69:537–557
Goodman C, Goetz FC (1970) Oral and intravenous D-ribose and plasma insulin in healthy humans: effects of route of administration and of epinephrine and propranolol. Metabolism 19:1094–1103
Halter JB, Schwarty MZ, Goetz FC (1968) The effect of oral and intravenous D-ribose on plasma insulin levels in unanesthetized dogs. Proc Soc Exp Biol Med 127:1147–1151
Gross M, Reiter S, Zöllner N (1989) Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 67:1205–1213
Helmreich E, Cori CF (1957) Studies on tissue permeability. II. The distribution of pentoses between plasma and muscle. J Biol Chem 224:663–679
Hiatt HH (1957) The pentose phosphate pathway in human metabolism. J Clin Invest 36:899
Hiatt HH (1958) Studies of ribose metabolism. III. The pathway of ribose carbon conversion to glucose in man. J Clin Invest 37:651–654
Kida Y, Esposito-Del Puente A, Bogardus C, Mott DM (1990) Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. J Clin Invest 85:476–481
Larson HW, Bradshaw PJ, Ewing ME, Sawyer SD, Blatherwick NR (1943) The metabolism of d-ribose. Fed Proc 2:66
Miller B (1974) Der D-Xylose-Test. In: Englhardt A, Lommel H (eds) Malabsorption. Maldigestion, Bd 2. Verlag Chemie, Weinheim, pp 155–163
Park CR, Johnson LH, Wright JH, Batsel H (1957) Effect of insulin on transport of several hexoses and pentoses into cells of muscle and brain. Am J Physiol 191:13–18
Pizzichini MR, Marcolongo R, Marinello E (1979) Ribose tolerance in gouty patients. J Clin Chem Clin Biochem 17:436
Pozza G, Galansino G, Hoffeld H, Foa PP (1958) Stimulation of insulin output by monosaccharides and monosaccharide derivates. Am J Physiol 192:497–500
Roe JH, Rice EW (1948) A photometric method for the determination of free pentoses in animal tissues. J Biol Chem 173:507–512
Segal S, Foley J, Wyngaarden JB (1957) Hypoglycemic effect of D-ribose in man. Proc Soc Exp Biol Med 95:551–555
Segal S, Wyngaarden JB, Foley J (1957) The effect of insulin on blood levels of infused pentoses in man. J Clin Invest 36:1383–1394
Segal S, Foley J (1958) The metabolism of D-ribose in man. J Clin Invest 37:719–735
Steinberg T, Ortman P, Poucher R, Cochran B, Gwinup G (1967) The effect of D-ribose infusion on serum immuno-reactive insulin and glucose concentration. Metabolism 16:40–46
Wuest HM, Solmssen UV (1946) The urinary excretion of d-ribose in man. Arch Biochemistry 11:199–201
Zöllner N, Reiter S, Gross M, Pongratz D, Reimers CD, Gerbitz K, Paetzke I, Deufel T, Hübner G (1986) Myoadenylate deaminase deficiency:successful symptomatic therapy by high dose oral administration of ribose. Klin Wochenschr 64:1281–1290
This paper was supported by a grant from the Friedrich-Baur-Stiftung, Federal Republic of Germany
About this article
Cite this article
Gross, M., Zöllner, N. Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man. Klin Wochenschr 69, 31–36 (1991). https://doi.org/10.1007/BF01649054