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Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man


D-ribose was given orally and/or intravenously to nine healthy subjects at doses ranging from 83.3 to 222.2 mg/kg per hour for at least four hours. The serum ribose level increased in a dose-dependent manner to maximum concentrations of 75 to 85 mg/dl. The serum glucose level decreased after the beginning of continuous ribose administration and was reduced as long as ribose was being administered. The oral or intravenous administration of 166.7 mg/kg per hour of ribose resulted in a 25% decrease in serum glucose. Higher intravenous doses of ribose did not provoke a further decrease in serum glucose concentration. Oral administration of 166.7 mg/kg per hour led to an increase in serum insulin concentrations from a mean of 8.4 (range 6.4–11.5) to 10.4 (range 6.3–15.4) μU/ml (p<0.05). In contrast, intravenous administration did not change serum insulin concentrations significantly. The serum c-peptide concentration remained unchanged regardless of treatment. We conclude that the variations in plasma insulin concentrations do not account for the observed decrease in mean serum glucose concentrations accompanying D-ribose administration.

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  1. 1.

    Ginsburg J, Boucher B, Beaconsfield P (1970) Hormonal changes during ribose-induced hypoglycemia. Diabetes 19:23–27

  2. 2.

    Goetz FC, Maney JW, Greenberg BZ (1967) The regulation of insulin secretion: effects of the infusion of glucose, ribose, and other sugars into the portal veins of dogs. J Lab Clin Med 69:537–557

  3. 3.

    Goodman C, Goetz FC (1970) Oral and intravenous D-ribose and plasma insulin in healthy humans: effects of route of administration and of epinephrine and propranolol. Metabolism 19:1094–1103

  4. 4.

    Halter JB, Schwarty MZ, Goetz FC (1968) The effect of oral and intravenous D-ribose on plasma insulin levels in unanesthetized dogs. Proc Soc Exp Biol Med 127:1147–1151

  5. 5.

    Gross M, Reiter S, Zöllner N (1989) Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 67:1205–1213

  6. 6.

    Helmreich E, Cori CF (1957) Studies on tissue permeability. II. The distribution of pentoses between plasma and muscle. J Biol Chem 224:663–679

  7. 7.

    Hiatt HH (1957) The pentose phosphate pathway in human metabolism. J Clin Invest 36:899

  8. 8.

    Hiatt HH (1958) Studies of ribose metabolism. III. The pathway of ribose carbon conversion to glucose in man. J Clin Invest 37:651–654

  9. 9.

    Kida Y, Esposito-Del Puente A, Bogardus C, Mott DM (1990) Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. J Clin Invest 85:476–481

  10. 10.

    Larson HW, Bradshaw PJ, Ewing ME, Sawyer SD, Blatherwick NR (1943) The metabolism of d-ribose. Fed Proc 2:66

  11. 11.

    Miller B (1974) Der D-Xylose-Test. In: Englhardt A, Lommel H (eds) Malabsorption. Maldigestion, Bd 2. Verlag Chemie, Weinheim, pp 155–163

  12. 12.

    Park CR, Johnson LH, Wright JH, Batsel H (1957) Effect of insulin on transport of several hexoses and pentoses into cells of muscle and brain. Am J Physiol 191:13–18

  13. 13.

    Pizzichini MR, Marcolongo R, Marinello E (1979) Ribose tolerance in gouty patients. J Clin Chem Clin Biochem 17:436

  14. 14.

    Pozza G, Galansino G, Hoffeld H, Foa PP (1958) Stimulation of insulin output by monosaccharides and monosaccharide derivates. Am J Physiol 192:497–500

  15. 15.

    Roe JH, Rice EW (1948) A photometric method for the determination of free pentoses in animal tissues. J Biol Chem 173:507–512

  16. 16.

    Segal S, Foley J, Wyngaarden JB (1957) Hypoglycemic effect of D-ribose in man. Proc Soc Exp Biol Med 95:551–555

  17. 17.

    Segal S, Wyngaarden JB, Foley J (1957) The effect of insulin on blood levels of infused pentoses in man. J Clin Invest 36:1383–1394

  18. 18.

    Segal S, Foley J (1958) The metabolism of D-ribose in man. J Clin Invest 37:719–735

  19. 19.

    Steinberg T, Ortman P, Poucher R, Cochran B, Gwinup G (1967) The effect of D-ribose infusion on serum immuno-reactive insulin and glucose concentration. Metabolism 16:40–46

  20. 20.

    Wuest HM, Solmssen UV (1946) The urinary excretion of d-ribose in man. Arch Biochemistry 11:199–201

  21. 21.

    Zöllner N, Reiter S, Gross M, Pongratz D, Reimers CD, Gerbitz K, Paetzke I, Deufel T, Hübner G (1986) Myoadenylate deaminase deficiency:successful symptomatic therapy by high dose oral administration of ribose. Klin Wochenschr 64:1281–1290

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This paper was supported by a grant from the Friedrich-Baur-Stiftung, Federal Republic of Germany

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Gross, M., Zöllner, N. Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man. Klin Wochenschr 69, 31–36 (1991). https://doi.org/10.1007/BF01649054

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Key words

  • (D-)ribose
  • Glucose
  • Insulin
  • C-peptide