Klinische Wochenschrift

, Volume 68, Issue 2, pp 142–145 | Cite as

Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats

  • K. Dakshinamurti
  • S. K. Sharma
  • D. Bonke


Treatment of normal adult rats with pyridoxine or a B-vitamin mixture resembling Neurobion® 1 led to an increase in serotonin content of various brain areas and to a decrease in the number of serotonin S2 receptors. The results indicate that the pyridoxal phosphate level in regions of the brain regulates the extent of decarboxylation of 5-hydroxytryptophan, the precursor of serotonin. The results also suggest a continuum from deficiency in pyridoxine to treatment of animals with a moderate excess of pyridoxine which is reflected in the synthesis and secretion into the synaptic cleft of the neurotransmitter serotonin.

Key words

Pyridoxine B Vitamins CNS Serotonin receptor binding Rat 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • K. Dakshinamurti
    • 1
  • S. K. Sharma
    • 1
  • D. Bonke
    • 2
  1. 1.Department of Biochemistry and Molecular Biology, Faculty of MedicineUniversity of ManitobaWinnipegCanada
  2. 2.E. Merck, Clinical Drug DevelopmentDarmstadt

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