, Volume 12, Issue 6, pp 381–383

The combination of pivmecillinam and pivampicillin in the treatment of enteric fever

  • D. Tanphaichitra
  • S. Srimuang
  • P. Chiaprasittigul
  • P. Menday
  • O. E. Christensen


Thirty-nine patients with acute enteric fever received the fixed-dose oral combination of pivmecillinam/pivampicillin. Thirty-seven (95%) subjects responded satisfactorily. No relapses or persistent faecal excretion of salmonellae were seen in the 29 patients followed up for 2 to 19 weeks. The treatment was well tolerated, no side-effects being recorded.In vitro studies revealed a synergistic interaction between mecillinam and ampicillin against isolates ofSalmonella paratyphi A.

Kombination von Pivmecillinam und Pivampicillin zur Behandlung des Typhus


39 Patienten mit akutem Typhus abdominalis erhielten eine fixe orale Kombination von Pivmecillinam/Pivampicillin. Ein befriedigendes Therapieergebnis wurde bei 37 Patienten (95%) erzielt. 29 Patienten, die zwei bis 19 Wochen lang nachbeobachtet wurden, bekamen keine Rückfälle, eine persistierende Ausscheidung von Salmonellen im Stuhl wurde nicht festgestellt. Die Medikation wurde gut vertragen, Nebenwirkungen wurden nicht beobachtet. Mecillinam und Ampicillin ließen inIn vitro-Studien eine synergistische Wirkung gegen Isolate vonSalmonella paratyphi A erkennen.


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  1. 1.
    Anderson, E. S., Smith, H. R. Chloramphenicol resistance in the typhoid bacillus. Br. Med. J. 3 (1972) 329–331.Google Scholar
  2. 2.
    Butler, T., Linh, N. N., Arnold, K., Pollack, M. Chloramphenicol resistant typhoid fever in Vietnam associated with R-factor. Lancet II (1973) 983–985.Google Scholar
  3. 3.
    Tanphaichitra, D., Siristonupum, Y., Tanphaichitra, V., Sukathat, O. Typhoid fever: Report of 511 cases — complications, antibiotigram and clinical trial with mecillinam/ampicillin combination. In: Current chemotherapy of infectious diseases. American Society for Microbiology, Washington D.C. 1980, pp. 926–927.Google Scholar
  4. 4.
    Tanphaichitra, D., Bussayond, A., Christensen, O. The combination of pivmecillinam and pivampicillin in the treatment of acute enteric fevver. J. Antimicrob. Chemother. 8 (1981) 23–28.Google Scholar
  5. 5.
    Limson, B. M., Mendoza, M. T., Liwanag, E., Christensen, O. E., Menday, P. Randomized comparative trial of mecillinam, mecillinam/ampicillin and chloramphenicol in the tratment of enteric fever. J. Antimicrob. Chemother. 9 (1982) 405–410.Google Scholar
  6. 6.
    Tanphaichitra, D., Bussayanond, A., Christensen, O. The combination of pivmecillinam and pivampicillin compared to co-trimoxazole in the treatment of enteric fever. Infection 10 (1982) 82–84.Google Scholar
  7. 7.
    Limson, B. M., Mendoza, M. T., Christensen, O. E.: Miraxid in enteric fever, including drug-resistant salmonellosis. Presented at 13th International Congress of Chemotherapy, Vienna, 25th August – 2nd September, 1983.Google Scholar
  8. 8.
    Waki, S., Ultima, M., Muto, Y., Ishigaki, J., Rin, T., Sameshima, Y. Biliary excretion of pivmecillinam and amoxycillin. Chemotherapy 25 (1977) 205–208.Google Scholar
  9. 9.
    Bukh, N. Double-blind comparison of pivmecillinam plus pivampicillin (Miraxid) with pivampicillin alone in chronic bronchitis: a Danish multi-centre study. Pharmatherapeutica 3 (1983) 385–394.Google Scholar
  10. 10.
    Saltvedt, E. P., Schøyen, R. Pivmecillinam plus pivampicillin in urinary tract infections. A double-blind comparison with pivmecillinam alone in hospitalized patients. Infection 10 (1982) 21–22.Google Scholar

Copyright information

© MMV Medizin Verlag GmbH München 1984

Authors and Affiliations

  • D. Tanphaichitra
    • 1
  • S. Srimuang
    • 1
  • P. Chiaprasittigul
    • 1
  • P. Menday
    • 2
  • O. E. Christensen
    • 3
  1. 1.Ramathibodi Medical SchoolMahidol University Medical CentreBangkokThailand
  2. 2.Leo Laboratories LimitedPrinces RisboroughAylesburyEngland
  3. 3.Department of PaediatricsHolbaek HospitalHolbaekDenmark

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