Enterotoxigenic escherichia coli in sweden
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Summary
The adrenal cell test for detection of heat-labile enterotoxin-producing Escherichia coli was performed on faecal specimens collected over a period of six months from 648 patients with diarrhoea. The patients came from all parts of Sweden. A total of 72 enterotoxigenic strains were found in 27 patients. Enterotoxigenic strains do not seem to be an important cause of diarrhoea in Sweden, since 70% of the patients with enterotoxin-producing strains had been abroad. Enterotoxigenic enterobacteria were the cause of traveller's diarrhoea in 11% of the patients who had been abroad with a peak incidence in July and August when traveller's diarrhoea was associated with enterotoxigenic strains in 17% of the patients. A simplified method for screening a large number of specimens for enterotoxin production was evaluated and found to be useful.
Keywords
Public Health Escherichia Coli Internal Medicine Infectious Disease General PracticeEnterotoxische Escherichia coli in Schweden
Zusammenfassung
Der Adrenal-Zellen-Test zum Nachweis von hitzelabilem enterotoxin-bildendem Escherichia coli wurde bei 648 Patienten mit Durchfall in einem Zeitraum von sechs Monaten in ganz Schweden durchgeführt. Insgesamt wurden bei 27 Patienten 72 Enterobakterienstämme, die hitzelabiles Enterotoxin produzieren, gefunden. Diese Stämme sind jedoch nicht ausschlaggebend für Diarrhöe in Schweden, da 70% der Patienten mit enterotoxin-bildenden Stämmen sich vorher im Ausland aufhielten. Enterotoxin-bildende Enterobakterien waren Ursache für „traveller's diarrhoea“ bei 11% dieser Patienten. Die höchste Inzidenz war in den Monaten Juli und August, als bis zu 17% der Patienten mit „travellers' diarrhoea“ enterotoxin-erzeugende Bakterien aufweisen. Eine vereinfachte Screening-Methode zur Untersuchung einer größeren Anzahl von Stuhlproben im Hinblick auf Enterotoxinproduktion wurde mit gutem Erfolg durchgeführt.
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Literatur
- 1.DuPont, H. L., Formal, S. B., Hornich, R. B., Snyder, M. J., Libonati, J. P., Sheahan, D. G., LaBrec, E. H., Kalas, J. P. Pathogenesis of Escherichia coli diarrhea. N. Engl. J. Med. 285 (1971) 1–9.CrossRefPubMedGoogle Scholar
- 2.Sack, R. B., Gorbach, S. L., Banwell, J. G., Jacobs, B., Chatterjee, B. D., Mitra, R. C. Enterotoxigenic Escherichia coli isolated from patients with severe cholera-like disease. J. Inf. Dis. 123 (1971) 378–385.CrossRefGoogle Scholar
- 3.Nalin, D. R., McLaughlin, J. C., Rahman, M., Ynus, M., Curlin, G. Enterotoxigenic Escherichia coli and idiopathic diarrhoea in Bangladesh. Lancet (1975/II) 1116–1118.CrossRefGoogle Scholar
- 4.Ryder, R. W., Sack, D. A., Kapikian, A. Z., McLaughlin, J. C., Chakrabarty, J., Rahman, M., Merson, H. M., Wells, J. G. Enterotoxigenic Escherichia coli and reovirus-like agent in rural Bangladesh. Lancet (1976/I) 659–662.CrossRefGoogle Scholar
- 5.Gorbach, S. L., Khurana, C. M. Toxigenic Escherichia coli, a cause of infantile diarrhea in Chicago. N. Engl. J. Med. 287 (1972) 791–795.CrossRefPubMedGoogle Scholar
- 6.Dean, A. G., Ching, Y-C., Williams, R. G., Harden, L. B. Test for Escherichia coli enterotoxin using infant mice application in a study of diarrhea in children in Honolulu. J. Inf. Dis. 125 (1972) 407–411.CrossRefGoogle Scholar
- 7.Echeverria, R., Blacklow, N. R., Smith, D. H. Role of heatlabile toxigenic Escherichia coli and reovirus-like agent in diarrhoea in Boston children. Lancet (1975/II) 1113–1115.CrossRefGoogle Scholar
- 8.Guerrant, R. L., Moore, R. A., Kirschenfeld, P. M., Sande, M. A. Role of toxigenic and invasive bacteria in acute diarrhea of childhood. N. Engl. J. Med. 293 (1975) 567–573.CrossRefPubMedGoogle Scholar
- 9.Sack, R. B., Hirschhorn, N., Brownlee, I., Cash, R. A., Woodward, W. E., Sack, D. A. Enterotoxigenic Escherichia coli-associated diarrheal disease in Apache children. N. Engl. J. Med. 292 (1975) 1041–1045.CrossRefPubMedGoogle Scholar
- 10.Gorbach, S. L., Kean, B. H., Evans, D. G., Evans, D. J., Bessudo, D. Traveller's diarrhea and toxigenic Escherichia coli. N. Engl. J. Med. 292 (1975) 933–936.CrossRefPubMedGoogle Scholar
- 11.Shore, E. G., Dean, A. G., Holik, K. J., Davis, B. R. Enterotoxin-producing Escherichia coli and diarrheal disease in adult travellers: A prospective study. J. Inf. Dis. 129 (1974) 577–582.CrossRefGoogle Scholar
- 12.Gästrin, B., Kallings, L. O., Marcetic, A. The survival time for different bacteria in various transport media. Acta Pathol. Microbiol. Scand. 74 (1968) 371–380.CrossRefPubMedGoogle Scholar
- 13.Wadström, T., Aust-Kettis, A., Habte, D., Meeuwisse, G., Holmgren, J. Möllby, R., Söderlind, O. Enterotoxin-producing bacteria and parasites in stools of Ethiopian children with diarrhoeal disease. Arch. Dis. Child. 51 (1976) 865–870.CrossRefPubMedPubMedCentralGoogle Scholar
- 14.Sack, D. A., Sack, R. B. Test for enterotoxigenic Escherichia coli using Y1 adrenal cells in minicultures. Infect. Immun. 11 (1975) 334–336.PubMedPubMedCentralGoogle Scholar
- 15.Söderlind, O., Möllby, R., Wadström, T. Purification and some properties of the heat-labile enterotoxin from Escherichia coli. Zbl. Bact. Hyg. I Abt. Orig. A 229 (1974) 190–204.Google Scholar
- 16.Edwards, P. R., Erwing, W. H. Identification of enterobacteriacae, Publ. Comp. Burgess, Minneapolis 1972.Google Scholar
- 17.Rudoy, R. C., Nelson, J. D. Enteroinvasive and enterotoxigenic Escherichia coli. Occurrence in acute diarrhea of infants and children. Amer. J. Dis. Child. 129 (1975) 668–672.CrossRefPubMedGoogle Scholar
- 18.Sack, D. A., Merson, M. H., Wells, J. G., Sack, R. B., Morris, G. K. Diarrhoea associated with heat-stable enterotoxin-producing strains of Escherichia coli. Lancet (1975/II) 239–241.CrossRefGoogle Scholar
- 19.Merson, M. H., Morris, G. K., Sack, D. A., Wells, J. G., Feeley, J. C., Sack, R. B., Creech, W. B., Kapikian, A. Z., Gangarosa, E. J. Traveller's diarrhea in Mexico. N. Engl. J. Med. 294 (1976) 1299–1305.CrossRefPubMedGoogle Scholar