Osteoporosis International

, Volume 2, Issue 1, pp 48–53

Screening for vertebral osteoporosis using individual risk factors

  • C. Cooper
  • S. Shah
  • D. J. Hand
  • J. Adams
  • J. Compston
  • M. Davie
  • A. Woolf
Original Article

Abstract

Osteoporosis is a major cause of ill health in postmenopausal women. Several risk factors for osteoporosis have been identified, and they have been widely recommended as a means of identifying subgroups of postmenopausal women who might benefit from prophylaxis and therapy. Evidence to support this use of risk factors is currently lacking, however. We have constructed and evaluated a profile of putative risk factors as a means of identifying women attending general practitioners who have sustained vertebral fractures. The overall prevalence of vertebral fractures in the 1012 women (mean age 64.4 years) studied was 7.8%. Women who had sustained vertebral fractures in this population were significantly (p<0.05) older and shorter than those without fractures. They reported a significantly (p<0.05) earlier menopause, lower parity and a greater prevalence of hyperthyroidism. However, the best screening instrument devised was not sufficiently predictive to warrant widespread use.

Keywords

Risk factors Screening Vertebral fractures Osteoporosis 

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Copyright information

© European Foundation for Osteoporosis 1991

Authors and Affiliations

  • C. Cooper
    • 1
  • S. Shah
    • 2
  • D. J. Hand
    • 3
  • J. Adams
    • 4
  • J. Compston
    • 5
  • M. Davie
    • 6
  • A. Woolf
    • 7
  1. 1.Rheumatology UnitBristol Royal InfirmaryUK
  2. 2.Medical Department, Sandoz PharmaceuticalsUK
  3. 3.Faculty of MathematicsThe Open UniversityMilton Keynes
  4. 4.Department of Diagnostic RadiologyUniversity of Manchester Medical SchoolUK
  5. 5.Department of MedicineUniversity of Cambridge Medical SchoolUK
  6. 6.Robert Jones and Agnes Hunt Orthopaedic HospitalOswestry
  7. 7.Royal Cornwall Hospital (City)TruroUK
  8. 8.Section of Clinical Epidemiology, Department of Health Sciences Research, Mayo ClinicRochesterUSA

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