Presence of oestrogen receptors on target cells and antiproliferative activity of estramustine phosphate: Positive correlation for human tumours in vitro

  • J. Pavelić
  • I. Zgradić
  • K. Pavelić
Original Papers Experimental Oncology


Incubation with estramustine phosphate for 24 h inhibited DNA, RNA and protein synthesis in primary cultures of human kidney, mammary, prostatic, cervical and endometrial carcinoma. Not only the presence, but also the concentration of oestrogen receptors correlated with estramustine phosphate effects on tumour cell proliferation.

Key words

Oestrogen receptors Estramustine phosphate Human tumours 



oestrogen receptor


estramustine phosphate


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • J. Pavelić
    • 1
  • I. Zgradić
    • 1
  • K. Pavelić
    • 1
  1. 1.Ruter Bošković InstituteZagrebYugoslavia

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