International Journal of Biometeorology

, Volume 32, Issue 1, pp 17–20 | Cite as

Epilepsy and electromagnetic fields: effects of simulated atmospherics and 100-Hz magnetic fields on audiogenic seizure in rats

  • J. Juutilainen
  • E. Björk
  • K. Saali
Original Articles


In order to study the possible association between epileptic seizures and natural electromagnetic fields, 32 female audiogenic seizure (AGS)-susceptible rats were exposed to simulated 10 kHz and 28 kHz atmospherics and to a sinusoidally oscillating magnetic field with a frequency of 100 Hz and field strength of 1 A/m. After the electromagnetic exposure, seizures were induced in the rats with a sound stimulus. The severity of the seizure was determined on an ordinal scale, the audiogenic response score (ARS). The time from the beginning of the sound stimulus to the onset of the seizure (seizure latency) and the duration of the convulsion was measured. No differences from the control experiments were found in the experiments with simulated atmospherics, but the 100 Hz magnetic field increased the seizure latency by about 13% (P<0.02). The results do not support the hypothesis that natural atmospheric electromagnetic signals could affect the onset of epileptic seizures, but they suggest that AGS-susceptible rats may be a useful model for studying the biological effects of electromagnetic fields.

Key words

Epilepsy Electromagnetic fields Rat Audiogenic seizure 


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  1. Adey WR (1981) Tissue interactions with nonionizing electromagnetic fields. Physiol Rev 61:435–514.Google Scholar
  2. Baumer H, Eichmeier J (1982) The biophysically active wave-forms of atmospherics incident on gelatin films. Int J Biometeorol 26:85–90.Google Scholar
  3. Björk EA, Tacke U (1985) Sounds with harmonic spectra are more effective than pure tones in inducing audiogenic seizure in rats. Hear Res 17:95–98Google Scholar
  4. Gerth C, Schlykowa L, Thoss F, Drischel H (1983) Der Einfluß eines magnetischen Wechselfeldes auf Ausbildung und Erlöschen bedingter Reaktionen bei Ratten. Biomed Biochim Acta 42:1199–1204Google Scholar
  5. Jacobi E, Richter O, Kruskemper G (1981) Simulated VLF fields as a risk factor for thrombosis. Int J Biometeorol 25:133–142Google Scholar
  6. Jobe PC (1981) Pharmacology of audiogenic seizures. In: Brown RD, Daigneult FA (eds) Pharmacology of hearing: experimental and clinical bases. Wiley Interscience. New York, pp 271–304Google Scholar
  7. Juutilainen J, Harri M, Saali K, Lahtinen T (1986) Effects of 100-Hz magnetic fields with various waveforms on the development of chick embryos. Radia Environ Biophys 25:65–74Google Scholar
  8. König HL (1974) VLF signal properties: Physical characteristics. In: Persinger MA (ed) ELF and VLF electromagnetic field effects. Plenum Press, New York, pp 9–34Google Scholar
  9. Krushinsky LV, Molodkina LN, Fless DA, Dobrokhotova LP, Steshenko AP, Semiokhina AF, Zorina AF, Romanova LG (1970) The functional state of the brain during sonic stimulation. In: Welch BL, Welch AA (eds) Physiological effects of noise. Plenum Press, New York, pp 159–183Google Scholar
  10. Ludwig HW (1974) Electric and magnetic field strengths in the open and in shielded rooms in the ULF to LF zone. In: Persinger MA (ed) ELF and VLF electromagnetic field effects. Plenum Press, New York, pp 35–80Google Scholar
  11. Marino AA, Becker RO (1977) Biological effects of extremely low frequency electric and magnetic fields: a review. Physiol Chem Phys 9:131–147Google Scholar
  12. Richner H, Graber W (1978) The ability of non-class ial meteorological parameters to penetrate into buildings. Int J Biometeorol 22:242–248Google Scholar
  13. Ruhenstroth-Bauer G, Baumer H, Kugler J, Spatz R, Sönning W, Filipiak B (1984) Epilepsy and weather: a significant correlation between the onset of epileptic seizures and specific atmospherics — a pilot study. Int J Biometeorol 28:333–340Google Scholar
  14. Saali K, Juutilainen J, Lahtinen T (1986) A system for exposing biological objects to variable combinations of electric and magnetic fields. J Bioelectr 5:171–186Google Scholar
  15. Tacke U, Björk E, Tuomisto J (1984) The effect of changes in sound pressure level and frequency on the seizure response of audiogenic seizure susceptible rats. J Pharmacol Methods 11:279–290Google Scholar

Copyright information

© International Society of Biometeorology 1988

Authors and Affiliations

  • J. Juutilainen
    • 1
  • E. Björk
    • 1
  • K. Saali
    • 1
  1. 1.Department of Environmental HygieneUniversity of KuopioKuopioFinland

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