Osteoporosis International

, Volume 2, Issue 2, pp 103–105

Bone mineral density of the proximal femur and lumbar spine in glucocorticoid-treated asthmatic patients

  • I. R. Reid
  • M. C. Evans
  • D. J. Wattie
  • R. Ames
  • T. F. Cundy
Original Article

DOI: 10.1007/BF01623844

Cite this article as:
Reid, I.R., Evans, M.C., Wattie, D.J. et al. Osteoporosis Int (1992) 2: 103. doi:10.1007/BF01623844

Abstract

The importance of the proximal femur as a site of osteoporotic fractures, the development of techniques for bone mineral density (BMD) measurement at this site and the apparent selectivity of the osteopenic effects of glucorticoids have focused attention on the assessment of proximal femoral BMD in steroid-treated subjects. We have, therefore, measured BMD (Lunar DPX) in the lumbar spine and proximal femur of 31 asthmatic patients receiving long-term glucocorticoid therapy (mean ± SEM dose 16 ± 1 mg prednisone/day, mean duration 10 ± 2 years). BMD values expressed as the percentage of normal age- and sex-appropriate mean values, after weight adjustment, were as follows: lumbar spine 80 ± 2%, femoral neck 83 ± 2%, Ward's triangle 78 ± 3% and trochanter 86 ± 2%. All these values were significantly less than control (p<0.0001) and the decrement in BMD was more marked in Ward's triangle than at the other two femoral sites (p<0.05). In all regions BMD was unrelated to dose or duration of steroid treatment. It is concluded that there are reductions in the BMD of the lumbar spine and proximal femur in glucocorticoid-treated asthmatics, probably reflecting the mixed cortical/trabecular makeup of both regions.

Keywords

Bone mineral density Steroid 

Copyright information

© European Foundation for Osteoporosis 1992

Authors and Affiliations

  • I. R. Reid
    • 1
  • M. C. Evans
    • 1
  • D. J. Wattie
    • 1
  • R. Ames
    • 1
  • T. F. Cundy
    • 1
  1. 1.Department of MedicineUniversity of AucklandAucklandNew Zealand

Personalised recommendations