Osteoporosis International

, Volume 3, Issue 3, pp 154–159 | Cite as

Age-related differences in total and regional bone mass: A cross-sectional study with DXA in 429 normal women

  • H. Rico
  • M. Revilla
  • L. F. Villa
  • M. Alvarez de Buergo
Original Article

Abstract

Total body bone mineral content (TBBMC), total body bone mineral density (TBBMD) and regional bone mineral content (BMC) and density (BMD) were assessed by dual-energy X-ray absorptiometry (DXA) in 429 normal women aged 15–83 years, of whom 242 were premenopausal and 187 postmenopausal. The population was divided into 5-year age groups. In the premenopausal women no changes in TBBMC, TBBMD or regional BMC and BMD were observed with age, and TBBMC and TBBMD values correlated well with body weight (p<0.001). Postmenopausal women showed an overall reduction in bone mass (p<0.001), more marked at the axial level than peripherally (1.6% vs. 0.8%/year). The values of TBBMC and TBBMD correlated well with chronological age, time since the onset of menopause and body weight (p<0.001). In these women age did not correlate with body weight, which suggests that postmenopausal bone mass loss depends more on chronological age and time since the onset of menopause than on other variables. The stability observed in bone mass values from ages 15–19 to menopause highlights the importance of stimulating the acquisition of an appropriate peak bone mass in women before adolescence begins.

Keywords

Body composition Bone densitometry Bone mass Dual-energy X-ray absorptiometry Postmenopausal bone loss 

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References

  1. 1.
    Gallagher JC. The pathogenesis of osteoporosis. Bone Miner 1990;9:215–7.Google Scholar
  2. 2.
    Halioua L, Anderson JJB. Age and anthropometric determinants of radial bone mass in premenopausal caucasian women: a cross-sectional study. Osteoporosis Int 1990;1:50–5.Google Scholar
  3. 3.
    Harrison JE, Patt N, Muller C, et al. Bone mineral mass associated with postmenopausal vertebral deformities. Bone Miner 1990;10:243–51.Google Scholar
  4. 4.
    Rodin A, Murby B, Smith MA, et al. Premenopausal bone loss in the lumbar spine and neck of femur: a study of 225 caucasian women. Bone 1990;11:1–5.Google Scholar
  5. 5.
    Hansson T, Roos B. Age changes in the bone mineral of the lumbar spine in normal women. Calcif Tissue Int 1986;38:249–51.Google Scholar
  6. 6.
    Block JE, Smith R, Glueer CC, Steiger P, Ettiger B, Genant H. Models of spinal trabecular bone loss as determined by quantitative computed tomography. J Bone Miner Res 1989;4:249–57.Google Scholar
  7. 7.
    Buchanan JR, Myers C, Lloyd T, Greer RB. Early vertebral trabecular bone loss in normal premenopausal women. J Bone Miner Res 1988;3:583–7.Google Scholar
  8. 8.
    Uebelhart D, Duboeuf F, Meunier PJ, Delmas PD. Lateral dual-photon absorptiometry: a new technique to measure the bone mineral density at the lumbar spine. J Bone Miner Res 1990;5:525–31.Google Scholar
  9. 9.
    Mazess RB, Barden HS, Bidek JP, Hanson J. Dual energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr 1990;51:1106–12.Google Scholar
  10. 10.
    Wahner HW. Clinically useful and readily available techniques for measurements of bone mineral and body composition by photon or X-ray obsorptiometry. Trends Endocrinol Metab 1990;1:382–7.Google Scholar
  11. 11.
    Sartoris DJ, Resnick D. Current and innovate methods for noninvasive bone densitometry, Radiol Clin North Am 1990;28:257–78.Google Scholar
  12. 12.
    Dawson-Hughes B, Deehr MS, Berger PS, Dallal GE, Sadowski LJ. Correction of the effects of source, source strength, and soft-tissue thickness on spine dual-photon absorptiometry measurements, Calcif Tissue Int 1989;44:251–7.Google Scholar
  13. 13.
    Gotfredsen A, Hadberg A, Nilas L, Christiansen C. Total body bone mineral in healthy adults. J Lab Clin Med 1987;110:362–8.Google Scholar
  14. 14.
    Matkovic V, Fontana D, Tominac C, Goel P, Chesnut CH. Factors that influence peak bone mass formation: a study of calcium balance and the inheritance of bone mass in adolescent females. Am J Clin Nutr 1990;52:878–88.Google Scholar
  15. 15.
    Block JE, Smith R, Glueer CC, Steiger P, Ettinger B, Genant H. Models of spinal trabecular bone loss as determined by quantitative computed tomography. J Bone Miner Res 1989;4:249–57.Google Scholar
  16. 16.
    Stevenson JC, Lees B, Devenport M, Cust MP, Ganger KF. Determinants of bone density in normal women: risk factors for future osteoporosis?. BMJ 1989;298:924–8.Google Scholar
  17. 17.
    Ribot C, Tremollieres F, Pouilles JM, Louvet JP, Guiraud R. Influence of the menopause and aging on spinal density in French women. Bone Miner 1988;5:89–97.Google Scholar
  18. 18.
    Rosenthal DI, Mayo-Smith W, Hayes CW, et al. Age and bone mass in premenopausal women. J Bone Miner Res 1989;4:533–8.Google Scholar
  19. 19.
    Mazess RB, Peppier WW, Chesney RW, Lange TA, Lindgren U, Smith E, Total body and regional bone mineral by dual-photon absorptiometry in metabolic disease. Calcif Tissue Int 1984;36:8–13.Google Scholar
  20. 20.
    Johnell O, Bjerre B, Jeppson S, Nilsson B, Rannevik G, Svanberg L. Pre- and postmenopausal changes in bone mass: a longitudinal study over 10 years. In: Christiansen C, Johansen JS, Riis BJ, editors. Osteoporosis 1987. Copenhagen: Osteopress ApS, 1987:150.Google Scholar
  21. 21.
    Nilas L, Gotfredsen A, Riis BJ, Christiansen C. The diagnostic validity of local and total bone mineral measurements in postmenopausal osteoporosis and osteoarthritis. Clin Endorcrinol 1986;25:711–20.Google Scholar
  22. 22.
    Geusens P, Dequeker J, Verstraeten A, Nijs J. Age-, sex-, and menopause-related changes of vertebral and peripheral bone: population study using dual and single photon absorptiometry and radiogrametry. J Nucl Med 1986;27:1540–9.Google Scholar
  23. 23.
    Cleghorn D, Nordin C, Morris H, Need A. Predictors of bone loss in a five year prospective study on postmenopausal women. Bone Miner 1990;10:S279.Google Scholar
  24. 24.
    Mazess RB, Barden HS, Interrelationships among bone densitometry sites in normal young women. Bone Miner 1990;11:347–56.Google Scholar
  25. 25.
    Mazess RB, Barden HS, Drinka PJ, Bauwens SF, Orwoll ES, Bell NH. Influence of age and bone weight on spine and femur bone mineral density in US white men. J Bone Miner Res 1990;5:645–52.Google Scholar

Copyright information

© European Foundation for Osteoporosis 1993

Authors and Affiliations

  • H. Rico
    • 1
  • M. Revilla
    • 1
  • L. F. Villa
    • 1
  • M. Alvarez de Buergo
    • 1
  1. 1.Department of Medicine and Rheumatology Unit of the ‘Príncipe de Asturias’ HospitalAlcalá de Henares UniversityMadridSpain

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