Journal of Cancer Research and Clinical Oncology

, Volume 117, Issue 6, pp 603–607

Genomic alterations of the c-myc protooncogene in relation to the overexpression of c-erbB2 and Ki-67 in human breast and cervix carcinomas

  • P. Münzel
  • D. Marx
  • H. Köchel
  • A. Schauer
  • K. W. Bock
Original Papers Clinical Oncology


Genomic alterations of c-myc (amplification, rearrangements and hypomethylation) were investigated in 30 breast carcinomas and 20 cervix carcinomas. In breast carcinomas c-myc alterations were compared with overexpression of the c-erbB2 protooncogene and the proliferation marker Ki-67. Alterations of c-myc were found in 50% of the breast carcinomas and in 25% of the cervix carcinomas. In 23% of the breast carcinomas c-erbB2 overexpression was associated with c-myc alterations. In 17% of the cases there was overexpression of c-erbB2 without detectable alterations of c-myc. Hence, in 67% of breast cancers alterations of c-myc and/or c-erbB2 have been found, while in 81% of the samples Ki-67 expression was increased. The results suggest that the study of c-myc alterations provides an important complement to that of other prognostic indicators of breast cancer such as c-erbB2 expression.

Key words

c-myc- c-erbB2 Ki-67 Breast cancer Cervix cancer 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • P. Münzel
    • 1
  • D. Marx
    • 2
  • H. Köchel
    • 3
  • A. Schauer
    • 2
  • K. W. Bock
    • 1
  1. 1.Institute of ToxicologyUniversity of TübingenTübingenGermany
  2. 2.Institute of PathologyUniversity of GöttingenGöttingenGermany
  3. 3.Institute of Hygiene and MicrobiologyUniversity of GöttingenGöttingenGermany

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