Advertisement

Virchows Archiv A

, Volume 422, Issue 2, pp 173–177 | Cite as

Granular cell basal cell carcinoma. Light microscopy, immunohistochemical and ultrastructural study

  • M. D. García Prats
  • M. López Carreira
  • M. A. Martínez-González
  • C. Ballestín
  • R. Gil
  • I. De Prada
Case Report

Summary

Granular cell basal cell carcinoma (BCC) is a rare histological variant of BCC. In this, the fifth reported case, a 67-year-old male with BCC located on the nose, light microscopy examination showed a tumour with the classical configuration of nodular BCC, in which most cells had finely granular eosinophilic cytoplasm. Ultrastructural observation showed numerous lysosome-like granules filling the cytoplasm of tumour cells, along with numerous well-formed pentalaminate desmosomes. Immunohistochemical profile (including positivity for keratins C 5.2 and AE 1 and for Leu-M1), together with the presence of cytoplasmic tonofilament bundles and desmosomes, are consistent with the proposed epithelial origin of granular cells in this tumour.

Key words

Basal cell carcinoma Skin tumours Granular cell tumours Granular cell basal cell carcinoma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abrikosoff A (1926) Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur. Virchows Arch [A] 360:215–233Google Scholar
  2. Barr RJ, Graham JH (1979) Granular cell basal cell carcinoma. Arch Dermatol 115:1064–1067Google Scholar
  3. Hartman KS (1974) Granular-cell ameloblastoma. A survey of twenty cases from the Armed Forces Institute of Pathology. Oral Surg 38:241–253Google Scholar
  4. Khansur T, Balducci L, Tavassoli M (1985) Identification of desmosomes in the granular cell tumor. Am J Surg Pathol 9:898–904Google Scholar
  5. Le Boit PE, Barr RJ, Bürall S, Metcalf JS, Yen TSB, Wick MR (1991) Primitive polypoid granular-cell tumor and other cutaneous granular cell neoplasms of apparent nonneural origin. Am J Surg Pathol 15:48–58Google Scholar
  6. Lever WF, Schaumburg-Lever (1990) Histopathology of the skin. Lippincott, Philadelphia, pp 582–593Google Scholar
  7. McWilliam LJ, Harris M (1985) Granular cell angiosarcoma of the skin: histology, electron microscopy and immunohistochemistry of a newly recognized tumor. Histopathology 9:1205–1216Google Scholar
  8. Mittal KR, True LD (1988) Origin of granules in granular cell tumor. Intracellular myelin formation with autodigestion. Arch Pathol Lab Med 112:302–303Google Scholar
  9. Mrak RE, Baker GF (1987) Granular cell basal cell carcinoma. J Cutan Pathol 14:37–42Google Scholar
  10. Reidbord HE, Wechsler HL, Fisher ER (1971) Ultrastructural study of basal cell carcinoma and its variants with comments on histogenesis. Arch Dermatol 104:132Google Scholar
  11. Sobel HJ, Marquet E (1974) Granular cells and granular cell lesions. In: Sommers SC (ed) Pathology annual, vol 9. Appleton-Century-Crofts, New York, pp 43–79Google Scholar
  12. Sobel HJ, Marquet E, Schwartz R (1973a) Is schwannoma related to granular cell myoblastoma? Arch Pathol 95:396–401Google Scholar
  13. Sobel HJ, Schwartz R, Marquet E (1973b) Light and electron microscope study of the origin of granular cell myoblastoma. J Pathology 109:101–111Google Scholar
  14. Suster S, Rosen LB (1988) Granular leiomyosarcoma of the skin. Am J Dermatopathol 10:234–239Google Scholar
  15. Wade TR, Ackerman AB (1978) The many faces of basal cell carcinoma. J Dermatol Surg Oncol 4:123–128Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • M. D. García Prats
    • 1
  • M. López Carreira
    • 1
  • M. A. Martínez-González
    • 1
  • C. Ballestín
    • 1
  • R. Gil
    • 1
  • I. De Prada
    • 1
  1. 1.Departamento de Anatomía PatológicaHospital Universitario 12 de OctubreMadridSpain

Personalised recommendations