Virchows Archiv A

, Volume 417, Issue 5, pp 369–375

Immunohistochemical localization of oestrogen receptors and progesterone receptors in the human ovary throughout the menstrual cycle

  • Toshiko Iwai
  • Yoshihiko Nanbu
  • Masazumi Iwai
  • Shunzou Taii
  • Shingo Fujii
  • Takahide Mori
Article

Summary

Immunohistochemistry was used to determine the distribution of oestrogen receptors (ER) and progesterone receptors (PR) in the human ovary during folliculogenesis. Primordial and preantral follicles did not contain ER or PR. The granulosa cells of antral follicles had ER, but negligible PR, before the LH surge. In contrast, at the time of LH surge, these cells of the dominant follicle contained PR, but not ER. On the other hand, granulosa cells of the non-dominant follicles had ER, but not PR. After ovulation, the PR persisted in the luteinized granulosa cells and in the corpus luteum during early pregnancy. The theca interna and surrounding stromal cells were ER-negative and PR-positive throughout the menstrual cycle. Thus, the results show that ER and PR are not expressed simultaneously in the granulosa cells, the thecal cells, or the stromal cells during folliculogenesis. Mechanisms controlling the expression of steroid receptors during the normal menstrual cycle and in early pregnancy are discussed.

Key words

Oestrogen receptor Progesterone receptor Human ovary Immunohistochemistry 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Toshiko Iwai
    • 1
  • Yoshihiko Nanbu
    • 1
  • Masazumi Iwai
    • 1
  • Shunzou Taii
    • 1
  • Shingo Fujii
    • 1
  • Takahide Mori
    • 1
  1. 1.Department of Gynecology and Obstetrics, Faculty of MedicineKyoto UniversityKyotoJapan

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