Virchows Archiv A

, Volume 418, Issue 5, pp 447–455 | Cite as

Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium

  • Rivka Levy
  • Bernard Czernobilsky
  • Benjamin Geiger


The aim of the present study was to explore the origin of cloacogenic carcinoma in the anal canal by immunohistochemical methods. We compared cytokeratin polypeptide expression of a cloacogenic carcinoma to normal anal epithelia, to anal squamous cell carcinoma and to basal and squamous cell carcinoma of the skin, using a battery of monoclonal anti-cytokeratin, polypeptide-specific antibodies. Our results indicate that cloacogenic carcinoma expresses cytokeratin polypeptides similar to those of the basal layer of anal squamous epithelium, of the anal transitional zone epithelium and of a layer of basal cells in the anal glands. Thus we concluded that each of the above cell types may be the cell of origin of cloacogenic carcinoma.

Key words

Cloacogenic carcinoma Anal Canal Cytokeratins Immunohistochemistry 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Rivka Levy
    • 1
  • Bernard Czernobilsky
    • 2
    • 3
  • Benjamin Geiger
    • 4
  1. 1.Department of Pathology, Faculty of MedicineTechnionHaifaIsrael
  2. 2.Department of PathologyKaplan HospitalRehovotIsrael
  3. 3.Medical School of the Hebrew University and HadassahJerusalem
  4. 4.Department of Chemical ImmunologyWeizmann Institute of ScienceRehovotIsrael

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