Acta Neurochirurgica

, Volume 43, Issue 3–4, pp 229–237 | Cite as

The mode of mitochondrial degeneration in gliomas

  • C. S. Foster
  • P. E. Spoerri
  • P. Glees
  • O. Spoerri


Morphologically abnormal mitochondria from human glial tumours are described. For each tumour both the appearances of the mitochondria, and the subsequent mode of degeneration and formation of osmiophilic pigment is characteristic.

The significance of these observations is discussed, and it is suggested that the mode of degeneration observed reflects directly a fundamental abnormality in composition compared to normal mitochondria.

Key words

Glioma mitochondria degeneration osmiophilic pigment 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ahmed, M., Glees, P., Mitochondrial degeneration after organic phosphate poisoning in prosimian primates. Cell. Tiss. Res.175 (1977), 459–465.Google Scholar
  2. Benhardt, W., Tournier, P., Modification persistante des mitochondries dans des cellules tumorales de Hamster transformées par l'adenovirus. 12 Int. J. Cancer1 (1966), 61.Google Scholar
  3. Brunk, U., Ericsson, J. L. E., Ponten, J., Westermark, B., Residual bodies and “aging” in cultures of human glia cells. Effect of entrance into phase and prolonged periods of confluence. Exp. Cell Res.79 (1973), 1–14.Google Scholar
  4. Chang, L. O., Schnaitman, C. A., Morris, H. P., Comparison of mitochondrial membrane proteins of rat liver and hepatomas. Cancer Res.31 (1971), 108–113.Google Scholar
  5. Peters, A., Palay, S. L., Webster, De F., The fine structure of the nervous system. New York: Harper and Row. 1970.Google Scholar
  6. Frederic, J., Recherches cytologiques sur le chondriome normal on soumis à l'experimentation dans des cellules vivantes cultivéesin vitro. Thèse Université de Liège, Faculté de Médecin (1958).Google Scholar
  7. Glees, P., Maturation and aging of vertebrate neurons. In: Metabolic compartmentation and neurotransmission (Berl, S., Clarke, D. D., Schneider, D., eds.). New York: Plenum. 1975.Google Scholar
  8. —, Hasan, M., Spoerri, P. E., Mitochondrial genesis of lipofuscin-evidence based on electron microscopic studies of brain, neural tissue culture and heart. J. Physiol. (Lond.)239 (1974), 87.Google Scholar
  9. Gopinath, G., Glees, P., Mitochondrial genesis of lipofuscin in the mesencephalic nucleus of the Vth nerve of aged rats. Acta Anat. (Basel)89 (1974), 14–20.Google Scholar
  10. Hasan, M., Glees, P., Genesis and dissolution of neuronal lipofuscin. Gerontologia18 (1972), 217–236.Google Scholar
  11. Novikoff, P. M., Novikoff, A. B., Quintana, N., Hauw, J., Golgi apparatus Gerl and lysosomes of neurons in rat dorsal root ganglia, studied by thick and thin section cytochemistry. J. Cell Biol.50 (1971), 859–886.Google Scholar
  12. Onodera, Y., Yamamoto, Y., Tomita, T., Miwa, T., Fatty acid composition in mitochondria of brain tumour (Japanese). Brain Nerve (Tokyo)27 (1975), 49–55.Google Scholar
  13. Spoerri, P. E., Glees, P., Neuronal aging in cultures, an electron microscopic study. Exp. Geront.8 (1973), 259–263.Google Scholar
  14. —, Glees, P., The effects of dimethylaminoethyl p-chlorophenoxy acetate on spinal ganglia neurons and satellite cells in culture. Mitochondrial changes in the aging neurons. An electron microscope study. Mechanisms of Ageing and Development3 (1974), 131–155.Google Scholar
  15. Wallach, D. F. H., Cellular membranes and tumour behaviour: a new hypothesis. Proc. nat. Acad. Sci. (Wash.)61 (1968), 868–874.Google Scholar
  16. Warburg, O., On the origin of cancer cells. Science123 (1956), 309–314.Google Scholar
  17. Wenner, C. E., Progress in tumour enzymology (Nord, E. F., ed.), Advanc. Enzymol.29 (1967), 321–390.Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • C. S. Foster
    • 1
    • 2
  • P. E. Spoerri
    • 1
  • P. Glees
    • 1
  • O. Spoerri
    • 1
  1. 1.Institute of Histology and NeuroanatomyUniversity of Göttingen and Neurosurgical ClinicGöttingenGermany
  2. 2.Department of Experimental PathologyGeneral HospitalPlymouth, DevonEngland

Personalised recommendations