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Relationship between outer membrane protein profiles and resistance to ceftazidime, imipenem, and ciprofloxacin inPseudomonas aeruginosa isolates from bacteremic patients

  • C. Gimeno
  • D. Navarro
  • F. Savall
  • E. Millás
  • M. A. Farga
  • J. Garau
  • R. Cisterna
  • J. García-de-Lomas
Notes

Abstract

Outer membrane protein (OMP) profiles of 122Pseudomonas aeruginosa isolates recovered from the blood of bacteremic patients were analyzed to relate alterations in the expression of OMPs with porin activity to resistance to imipenem, ceftazidime, and ciprofloxacin. Imipenem-resistant isolates lacked or expressed reduced amounts of porin OprD. In contrast, alterations of OMP profiles were absent in most ceftazidime-resistant isolates. Six of 12 ciprofloxacin-resistant isolates had normal OMP profiles. The remaining isolates showed alterations in the expression of either OprC, OprF, or OprD. In addition, imipenem- and ceftazidime-resistant isolates displayed a β-lactamase activity compatible with that of a group 1 chromosomal cephalosporinase.

Keywords

Internal Medicine Membrane Protein Outer Membrane Ceftazidime Imipenem 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • C. Gimeno
    • 1
  • D. Navarro
    • 1
  • F. Savall
    • 1
  • E. Millás
    • 1
  • M. A. Farga
    • 1
  • J. Garau
    • 2
  • R. Cisterna
    • 3
  • J. García-de-Lomas
    • 1
  1. 1.Department of Microbiology, School of MedicineUniversity HospitalValenciaSpain
  2. 2.Department of MedicineHospital de TarrassaBarcelonaSpain
  3. 3.Department of Microbiology, School of MedicineHospital de BasurtoBilbaoSpain

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