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The Psychiatric Quarterly

, Volume 36, Issue 1–4, pp 261–270 | Cite as

Two cases of malignant tumors with metastases apparently treated successfully with hypoglycemic coma

  • S. Koroljow
Article

Summary

The material presented here tends to show: (1) that the enzymes of malignant cells may be considered the key point in the problem of malignancy, and (2) that these enzymes can be inactivated by an increased concentration of ozygen, with the consequent destruction of malignant tissues.

The amount of clinical material presented is insignificant, but the results may warrant full-scale research in this field along clinical and biochemical lines. The following theses for further research in the area can be suggested:
  1. 1.

    If malignant tumors should prove to be enzymatic disorders, it might be possible to separate the enzymes from the malignant cells.

     
  2. 2.

    If the enzymes could be separated, their ability to reproduce malignant growths in normal tissues could be studied.

     
  3. 3.

    Other possibilities of destruction of the enzymes (not only by hyperoxygenation) could be studied and possibly found.

     
  4. 4.

    Clinical trials of the hypoglycemic method on selected volunteers with (mostly hopeless) cases of malignancies should be done on a large scale by experts on insulin coma treatment.

     

Keywords

Pure Oxygen Blood Sugar Level Tissue Fluid Malignant Growth Hypoglycemic Coma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. Accornero, F.: Experimental histopathological researches on insulin shock. Am. J. Psychiat., 94 (Suppl.): 130, 1938.Google Scholar
  2. Baker, A. B.: Cerebral damage in hypoglycemia. Am. J. Psychiat., 96: 109, 1939.Google Scholar
  3. Beiglböck, W., and Dussik, T.: The physiology of the hypoglycemic shock in the treatment of schizophrenia. Am. J. Pssychiat., 94 (Suppl.): 50, 1938.Google Scholar
  4. Bini, L.: Ulteriori Ricerche Biochimiche sul Coma Insulinico. Atti del Convegno sulla Tarapia Moderna della Schizofrenia. Milan. 1937.Google Scholar
  5. Boyd, W.: Textbook of Pathology. Chapter on tumors. Fifth edition. Philadelphia. 1950.Google Scholar
  6. Ferraro, A., and Jervis, G. A.: Brain pathology in four cases of schizophrenia treated with insulin.Psychiat. Quart., 13: 207, 1939.CrossRefGoogle Scholar
  7. —: Pathologic considerations on insulin treatment of schizophrenia. Am. J. Psychiat., 96: 103, 1939.Google Scholar
  8. Gammermeyer, J.: Über Gehiraveränderungen entstanden unter Sakelscher Insulintherapie bei einem Schizophrenen. Ztsch. Neur. u. Psychiat., 163: 617, 1938.CrossRefGoogle Scholar
  9. Goodman, L., and Gilman, A.: The Pharmacological Basis of Therapeutics. P. 699. New York. 1947.Google Scholar
  10. Haldane, J. S.: Respiration. P. 355. London. 1922.Google Scholar
  11. Kalinowsky, L. B., and Hoch, P. H.: Shock Treatments, Psychosurgery and Other Somatic Treatments in Psychiatry. Grune & Stratton. New York. 1952.Google Scholar
  12. Kobler, F.: Histologischer Gehirnbefund nach Insulincoma. Arch. f. Psychiat., 107: 688, 1938.CrossRefGoogle Scholar
  13. Koroljow, Surgis A.: An investigation of the role played by oxygen and by cellular respiration in hypoglycemic coma.Psychiat. Quart., 30: 123, 1956.PubMedCrossRefGoogle Scholar
  14. Leppien, R., and Peters, G.: Todesfall infolge Insulinschockbehandlung bei einem Schizophrenen. Ztsch. Neur. u. Psychiat., 160: 444, 1937.CrossRefGoogle Scholar
  15. MacLeod, J. J. R.: Physiology and Biochemistry in Modern Medicine. Pp. 83, 380, 384, and 401. Mosby. St. Louis. 1922.Google Scholar
  16. Morsier, G., and Mozer, J. J.: Lésions cérébrales mortelles par hypoglycemie au cours d'un traintement insulinique chez un morphinomane. Ann. de Méd., 39: 474, 1956.Google Scholar
  17. Sakel, M.: The nature and origin of the hypoglycemic treatment of psychoses. Am. J. Psychiat., 94 (Suppl.): 24, 1938.Google Scholar
  18. Schmid, H.: Histopathologic changes associated with insulin shock. Ann. méd.-psychol. (pt 2), 94:658, 1936.Google Scholar
  19. Steif, A., and Tokay, L.: Beiträge zur Histopathologie der experimentellen Insulinvergiftung. Ztsch. Neur. u. Psychiat., 139: 434, 1933.CrossRefGoogle Scholar
  20. Terzrüggen, A.: Anatomische Befunde bei spontanner Hypoglykämie. Beit. Path. Anat., 88: 57, 1936.Google Scholar
  21. Terplan, K.: Changes in the brain in fatal insulin shock. Arch. Pathol., 14: 131, 1932.Google Scholar
  22. Weil, A.; Liebert, E., and Heilbrunn, G.: Histopathologic changes in the brain in experimental hyperinsulinism. Arch. Neurol. and Psychiat., 39: 467–481, 1938.Google Scholar
  23. Wohlwill, F.: Über Hirnbefunde bei Insulinüberdosierung. Klin. Wchnschr., 7: 344, 1938.CrossRefGoogle Scholar
  24. Wortis, J., and Goldfarb, W.: Schizophrenic brain metabolism in the course of insulin shock treatment. N.Y.S.J. Med., 42: 1053, 1942.Google Scholar

Copyright information

© The Psychiatric Quarterly 1962

Authors and Affiliations

  • S. Koroljow
    • 1
  1. 1.New Brunswick

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