The Psychiatric Quarterly

, Volume 36, Issue 1–4, pp 261–270 | Cite as

Two cases of malignant tumors with metastases apparently treated successfully with hypoglycemic coma

  • S. Koroljow


The material presented here tends to show: (1) that the enzymes of malignant cells may be considered the key point in the problem of malignancy, and (2) that these enzymes can be inactivated by an increased concentration of ozygen, with the consequent destruction of malignant tissues.

The amount of clinical material presented is insignificant, but the results may warrant full-scale research in this field along clinical and biochemical lines. The following theses for further research in the area can be suggested:
  1. 1.

    If malignant tumors should prove to be enzymatic disorders, it might be possible to separate the enzymes from the malignant cells.

  2. 2.

    If the enzymes could be separated, their ability to reproduce malignant growths in normal tissues could be studied.

  3. 3.

    Other possibilities of destruction of the enzymes (not only by hyperoxygenation) could be studied and possibly found.

  4. 4.

    Clinical trials of the hypoglycemic method on selected volunteers with (mostly hopeless) cases of malignancies should be done on a large scale by experts on insulin coma treatment.



Pure Oxygen Blood Sugar Level Tissue Fluid Malignant Growth Hypoglycemic Coma 
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Copyright information

© The Psychiatric Quarterly 1962

Authors and Affiliations

  • S. Koroljow
    • 1
  1. 1.New Brunswick

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