Journal of Industrial Microbiology

, Volume 13, Issue 2, pp 77–82 | Cite as

Enhancement of mycobactericidal activity of glutaraldehyde with α,β-unsaturated and aromatic aldehydes

  • M. D. Gordon
  • R. J. Ezzell
  • N. I. Bruckner
  • J. M. Ascenzi
Article
Received:
Revised:
Accepted:

Summary

Several α,β-unsaturated and aromatic aldehydes were evaluated for antimicrobial activity usingMycobacterium bovis as the test strain. Activity of most of the compounds was determined in the presence and absence of 2% glutaraldehyde. Several compounds highly active against this organism, e.g. 2-pentenal, benzaldehyde, ando-phthalaldehyde showed rapid kill of >105 CFU ml−1 in 5 min. Activity of α,β-unsaturated compounds substituted in the β1 position showed increasing activity with increasing chain length. Of the aromatic aldehydes tested, benzaldehyde andp-dimethylamino benzaldehyde showed little activity alone, but when combined with 2% glutaraldehyde showed increased activity. Substituents added to the benzaldehyde ring (nitro, chloro, methyl, and methoxy) all detracted from the synergism, but still showed increased activity over the activity of 2% glutaraldehyde. The same affect was noted with disubstituted benzaldehyde compounds but not with substitutedo-phthaladehyde (2-formylformaldehyde).

Key words

Glutaraldehyde Mycobactericidal Aldehydes 
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Copyright information

© Society for Industrial Microbiology 1994

Authors and Affiliations

  • M. D. Gordon
    • 1
  • R. J. Ezzell
    • 1
  • N. I. Bruckner
    • 1
  • J. M. Ascenzi
    • 1
  1. 1.Research DivisionJohnson and Johnson Medical, Inc.ArlingtonUSA

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