World Journal of Urology

, Volume 8, Issue 4, pp 224–232

Biological effects of shock waves

  • F. Brümmer
  • Th. Bräuner
  • D. F. Hülser
Free Paper

Summary

Extracorporeal shock wave lithotripsy has become established worldwide as the method of choice for the treatment of nephrolithiasis and ureterolithiasis over the last 10 years. Although initial studies showed no damaging effects of the shock waves on organs and tissues, numerous recent reports have presented evidence for severe acute effects and chronic complications after shock wave treatment. The pathophysiological effects on kidneys and the histopathological effects on organs or tissues in man and animal, and also the effects on cells in culture and tumors are sumarized. Suspended and immobilized cell cultures were used to characterize and quantify the efficacy of shock wave. Extended applications of shock waves and possible modifications to shock wave generators are discussed.

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References

  1. 1.
    Abrahams C, Lipson SB, Ross LS (1988) The effects of shock wave lithotripsy (ESWL) on canine kidneys (abstract). J Urol 139:324Google Scholar
  2. 2.
    Arduan J, Garcia-Gamez A, Cebezas J, Morales Lopez A, Maestro Duran JL, Cabezas J, Carcelan F (1988) Renal (extra-intra) morphology before and after ESWL, evaluated by magnetic resonance imaging. Abstract 0-5, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988Google Scholar
  3. 3.
    Baba S, Hata M, Nakanoma T, Tazaki H (1988) Long-term bioeffects of extracorporeal shock waves on rat kidneys. Abstract 90, 21st Congress of the International Societ of Urology, Buenos Aires, 9.–14. 10. 1988Google Scholar
  4. 4.
    Baumgartner BR, Dickey KW, Ambrose SS, Walton KN, Nelson RC, Bernardino ME (1987) changes after extracorporeal shock wave lithotripsy: appearance on MR imaging. Radiology 163:531–534Google Scholar
  5. 5.
    Begun FP, Lawson RK (1989) Long term effects of electrohydraulic shock waves on renal function and blood pressure. Abstract, 07-2, 7th World Congress on Endourology and ESWL, Kyoto, 27–30. 11. 1989Google Scholar
  6. 6.
    Begun FP Lawson RK, Kearns CM, Thieu TM (1989) Electrohydraulic shock wave induced renal injury. J Urol 142:155–159Google Scholar
  7. 7.
    Berens ME, Schostock C, Hart L, Barshira Z, McCullough DL (1988) Effect of cell cycle and temperature on the antiproliferative effects of acoustic shock waves (SW) against human tumor cells (abstract). J Urol 139:304Google Scholar
  8. 8.
    Bräuner Th, Brümmer F, Hülser DF (1988) Einwirkung von Stoßwellen auf tierische Zellkulturen. Licht-und elektronenmikroskopische Untersuchungen (abstract). Biomed Tech (Berlin) [Suppl 2]:35Google Scholar
  9. 9.
    Bräuner Th, Brümmer, F, Hülser DF (1989) Histopathology of shock wave treated tumor cell suspensions and multicell tumor spheroids. Ultrasound Med Biol 15:451–460Google Scholar
  10. 10.
    Brendel W, Delius M, Goetz A (1987) Effect of shock waves on the microvasculature. Prog Appl Microcirc 12:41–50Google Scholar
  11. 11.
    Brewer SL, Atala AA, Ackerman DM, Steinbock GS (1988) Shock wave lithotripsy damage in human cadaver kidneys. J Endourol 2:333–339Google Scholar
  12. 12.
    Brümmer F, Bräuner Th, Brenner J, Hülser DF (1988) Effects of lithotripter-generated shock waves on L 1210 mouse leukemia cells detected by flow cytometry (abstract). Eur J Cell Biol 46 (Suppl 2212Google Scholar
  13. 13.
    Brümmer F, Brenner J, Bräuner Th, Hülser DF (1989) Effect of shock waves on suspended and immobilized L1210 cells. Ultrasound Med Biol 15:229–239Google Scholar
  14. 14.
    Brümmer F, Nesper M, Schiess K, Suhr D, Brenner J, Bräuner Th, Hülser DF (1989) Shock wave efficacy measured with a bioassay (abstract). Eur J Cell Biol 48 [Suppl 26]9Google Scholar
  15. 15.
    Brümmer F, Nesper M, Schiess K, Suhr D, Brenner J, Hülser DF (1989) Characterisation of shock wave efficiency with cell cultures. Abstract P 13-5, 7th World Congress on Endourology and ESWL, Kyoto, 27–30. 11. 1989Google Scholar
  16. 16.
    Brümmer F, Staudenraus J, Nesper M, Suhr D, Eisenmenger W, Hülser DF (1989) Biological effects and physical characterization of shock waves generated by an XL-1 experimental lithotripter. Proc Ultrasonics Int 89:1130–1135Google Scholar
  17. 17.
    Chaussy Ch, Schmied E, Jocham D, Fuchs G, Brendel W, Forssman B, Hepp W (1986) Extracorporeal shock wave lithotripsy. Karger, BaselGoogle Scholar
  18. 18.
    Chaussy ChG, Randazzo RF, Fuchs GJ (1986) The effects of extracorporeal shock waves on human renal carcinoma cells and normal human embryonic kidney cells (abstract). J Urol 139:320Google Scholar
  19. 19.
    Chaussy ChG, Randazzo RF, Fuchs GJ (1986) The effects of extracorporeal shock waves on FANFT bladder tumors in C3H/He mice (abstract). J Urol 139:289Google Scholar
  20. 20.
    Chinn SKB, Michaels EK, Fowler JE, Behnia R, Linde HW, Ray V (1988) Hemodynamic and adrenal response to shock wave energy (abstract). J Urol 139:324Google Scholar
  21. 21.
    Cole RS, Montgomery BSI (1989) The incidence of hypertension 29 months after renal ESWL. Abstract 07-3, 7th World Congress on Endourology and ESWL, Kyoto, 27.–30. 11. 1989Google Scholar
  22. 22.
    Coleman AJ, Saunder JE, Crum LA, Dyson M (1987) Acoustic cavitation generated by an extracorporeal shockwave lithotripter. Ultrasound Med Biol 13:69–76Google Scholar
  23. 23.
    Das G, Brich B, Garden P, Wickham JEA (1988) The biological effects of shockwave lithotripsy. Abstract 0-17, 6th World Congress on Endourology and ESWL, Paris, 1.-3. 9. 1988Google Scholar
  24. 24.
    Delius M, Enders G, Heine G, Stark J, Remberger K, Brendel W (1987) Biological effects of shock waves: lung hemorrhage by shock waves in dogs-pressure dependence. Ultrasound Med Biol 13:61–67Google Scholar
  25. 25.
    Delius M, Enders G, Xuan Z, Liebich HG, Brendel W (1988) Biolocial effects of shock waves: kidney damage by shock waves in dogs-dose dependence. Ultrasound Med Biol 14:117–122Google Scholar
  26. 26.
    Delius M, Weiss N, Gambihler S, Goetz A, Brendel W (1989) Tumor therapy with shock waves requires modified lithotripter shock waves. Naturwissenschaften 76:573–574Google Scholar
  27. 27.
    Di Cello V, Selli C, Fiorelli C, Nicita G, Carini M, Saltutti C, Fontanelli A, Rosi E, Doni A (1988) Study of fibrinolytic system changes following ESWL. Abstract 0-15, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988Google Scholar
  28. 28.
    Drach GW (1988) Side effects of shock-wave lithotripsy—an overview. Abstract 92, 21st Congress of the International Society of Urology, Buenos Aires, 9.–14. 10. 1988Google Scholar
  29. 29.
    Eisenberger F, Rassweiler J (1986) Extrakorporale Stoßwellenlithotripsie im Wandel. Akt Urol 17:229–233Google Scholar
  30. 30.
    Eisenberger F, Fuchs GJ, Gumpinger R, Miller K, Rassweiler J (1987) Urologische Steintherapie—ESWL und Endourologie. Thieme, StuttgartGoogle Scholar
  31. 31.
    Eisenmenger W (1961) Eine elektromagnetische Impulsschallquelle zur Erzeugung von Druckstößen in Flüssigkeiten und Festkörpern. Proceedings of the 3rd International Congress on Acoustics, Stuttgart, 1959, 326–329Google Scholar
  32. 32.
    Eisenmenger W (1962) Elektromagnetische Erzeugung von ebenen Druckstößen in Flüssigkeiten. Acustica 12:185–202Google Scholar
  33. 33.
    Eisenmenger W (1988) Methoden der Stoßwellenerzeugung und messung. Biomed Tech (Berlin) 33 (Suppl 2] 1–6Google Scholar
  34. 34.
    Ell C, Kerzel W, Heyder N, Rödl W, Langer H, Mischke U, Giedl J, Domschke W (1989) Tissue reactions under piezoelectric shockwave application for the fragmentation of biliary calculi. Gut 30:680–685Google Scholar
  35. 35.
    Fischer N, Müller HM, Gulhan A, Sohn M, Deutz FJ, Rubben H, Lutzeyer W (1988) Cavitation effects: possible cause of tissue injury during extracorporeal shock wave lithotripsy. J Endourol 2:215–220Google Scholar
  36. 36.
    Geldof AA, Voogt HJ de, Rao BR (1989) High energy shock waves do not affect either primary tumor growth or metastasis of prostate carcinoma, R 2237-MatLyLu. Urol Res 17:9–12Google Scholar
  37. 37.
    Grote R, Döhring W, Aeikens B (1986) Computertomographischer und sonographischer Nachweis von renalen und perirenalen Veränderungen nach einer extrakorporalen Stoßwellenlithotripsie. Fortschr Röntgenstr 144:434–439Google Scholar
  38. 38.
    Hahn EW, Riedlinger R, Mattern J, Ueberle W, Bak M, Peschke P, Lorenz A, Zuna I, Gerlach L, Volm M, Kaick G van, Lorenz WJ (1988) High energy pulsed ultrasound (HEPUS): cytotoxic effecs on rodent tumors. Biomed Tech (Berlin) 33 [Suppl 2]141–142Google Scholar
  39. 39.
    Haupt G, Haupt A, Donovan JM, Drach GW, Chaussy Ch (1989) Short-term changes of laboratory values after extracorporeal shock wave lithitropsy: a comparative study. J Urol 142:259–262Google Scholar
  40. 40.
    Holmes RP, Yeaman LD, Taylor RG, Lewis JC, McCullough DL (1988) Enhanced Adriamycin uptake by neutrophils exposed to shock waves (abstract). J Urol 139:304Google Scholar
  41. 41.
    Hülser DF, Brümmer F, Brenner J, Bräuner Th, Nesper M (1988) Zell-und Gewebsveränderungen durch eine Stoßwellenbehandlung. Biomed Tech (Berlin) 33 [Suppl 2]:7–10Google Scholar
  42. 42.
    Jaeger P, Deslarzes C, Ginalski JM (1988) Evidence by ureteral catheterization of subtile renal tubular dysfunction after ESWL. Abstract 0-8, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988Google Scholar
  43. 43.
    Jaeger P, Redha F, Uhlschmid G, Hauri D (1988) Morphological changes in canine kidneys following extracorporeal shock wave treatment. J Endourol 2:205–213Google Scholar
  44. 44.
    Janssens J, Baert L, De Geest H, Ector H (1988) Extracorporeal shock wave lithotripsy and cardiac arrhytmias. Abstract 0-14. 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988Google Scholar
  45. 45.
    Kaude JV, Williams CM, Millner MR, Scott KN, Finlayson B (1985) Renal morphology and function immediately after extracorporeal shock-wave lithotripsy. AJR 145:305–313Google Scholar
  46. 46.
    Kishimoto T, Yamamoto K, Sugimoto T, Yoshihara H, Maekawa M (1986) Side effects of extracorporeal shock-wave exposure in patients treated by extracorporeal shock-wave lithotripsy for upper urinary tract stone. Eur Urol 12:308–313Google Scholar
  47. 47.
    Knapp PM, Kulb TB, Lingeman JE, Newman DM, Mertz JHO, Mosbaugh PG, Steele RE (1988) Extracorporeal shock wave lithotripsy-induced perirenal hematomas. J Urol 139:700–703Google Scholar
  48. 48.
    Krongrad A, Saltzman B, Tannenbaum M, Droller MJ (1988) Enzymuria following extracorporeal shock wave lithotripsy (ESWL) (abstract). J Urol 139:324Google Scholar
  49. 49.
    Kurzweil SJ, Smith JE, Arsdalen K van (1988) Effects of extracorporeal shock waves on skeletal and renal growth in the infant rabbit (abstract). J Urol 139:325Google Scholar
  50. 50.
    Lingeman JE, Kulb TB (1987) Hypertension following extracorporeal shock wave lithitripsy (abstract). J Urol 137:142Google Scholar
  51. 51.
    Loening SA, Mardan AH, Holmes J, Lubaroff DM (1988) In vivo and in vitro effects of shock waves on dunning prostate tumors (abstract). J Urol 139:303Google Scholar
  52. 52.
    Loening SA, Mardan AH, Lubaroff DM (1988) In vivo pathological effects of high energy shock waves generated by an experimental extracorporeal shock wave lithotripter (abstract). J Urol 139:323Google Scholar
  53. 53.
    Marcellan R, Servio LI (1986) Evaluation of renal damage in extracorporeal lithotripsy by shock waves. Eur Urol 12:73–75Google Scholar
  54. 54.
    Mardan A, Loening S (1988) Pathological reactions in rats to highenergy shock waves: 1. Local tissue responses. Abstract 0-51, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988Google Scholar
  55. 55.
    Mardan A, Loening S (1988) Pathological reactions in rats to highenergy shock waves: 2. Systemic responses. Abstract O-52, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988Google Scholar
  56. 56.
    McCullough DL, Yeaman LD, Bo WJ, Assimos DG, Kroovand RL, Griffin AS, Furr EG (1988) Do extracorporeal shock waves affect fertility and fetal development? A study of shock wave effects on the rat ovary and fetus (abstract). J Urol 139:325Google Scholar
  57. 57.
    Morgan RT, Laudone VP, Heston WDW, Zeitz L, Fair WR (1988) Free radical production by high energy shock waves—comparison with ionizing irradiation. J Urol 139:186–189Google Scholar
  58. 58.
    Müller M (1987) Stoßwellenfokussierung in Wasser. Ph. D thesis, RWTH Aachen, FRGGoogle Scholar
  59. 59.
    Müller-Klieser W (1987) Multicellular spheroids. A review on cellular aggregates in cancer research. J Cancer Res Clin Oncol 113:101–122Google Scholar
  60. 60.
    Newman DM, Lingeman JE, Woods JR, Toth PD (1989) Blood pressure changes following extracorporeal shock wave lithotripsy and other forms of treatment for urolithiasis. Abstract 07-4, 7th World Congress on Endourology and ESWL, Kyoto, 27.–30. 11. 1989Google Scholar
  61. 61.
    Newman R, Hackett R, Senior D, Brock B, Feldman J, Sosnowski J, Finlayson B (1987) Pathologic effects of ESWL on canine renal tissue. Urology 29:194–200Google Scholar
  62. 62.
    Oosterhof GON, Smits GAHJ, Ruyter JE de, Morselaar RJA, Schalken JA, Debruyne FMM (1989) The in vitro effect of electromagnetically generated shock waves (lithostar) on the Dunning R3327 PAT-2 rat prostatic cancer cell-line. Urol Res 17:13–19Google Scholar
  63. 63.
    Peschke P, Hahn EW, Lorenz WJ, Debus J, Zabel HJ, Ifflaender H, Lorenz A, Kaick G van, Pfeiler M (1989) Pulsed high energy ultrasound shock-waves (PHEUS): biological effects on the Dunning prostate rat tumor. Abstract P 13-7, 7th World Congress on Endourology and ESWL, Kyoto, 27.–30. 11. 1989Google Scholar
  64. 64.
    Ponchon T, Barkun AN, Berger F, Ayela P, Margonari J, Capron F (1989) Experimental tissue lesions related to extracorporeal lithotripsy of gallbladder. Surg Gynecol Obstet 169:435–441Google Scholar
  65. 65.
    Randazzo RR, Chaussy CG, Fuchs GJ, Bhuta SM, Lovrekovich H., de Kernion JB (1988) The in vitro and in vivo effects of extracorporeal shock waves on malignant cells. Urol Res 16:419–426Google Scholar
  66. 66.
    Rassweiler J, Westhauser A, Bub P, Eisenberger F 81988) Secondgeneration lithitropters: a comparative study. J Endourol 2:193–204Google Scholar
  67. 67.
    Recker F, Rübben H, Hofstädter F, Bex A (1988) Ultramorphological acute and long term lesions of ESWL in rat kidney. Abstract 0-54, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988Google Scholar
  68. 68.
    Recker F, Ruebben H, Neuerburg J, Bex A, Deutz FJ, Hofstaedter F (1990) Magnetic resonance imaging of acute and long-term alterations following extracorporeal shock wave lithotripsy in rats. Urol Int 4:28–33Google Scholar
  69. 69.
    Riedlinger R, Ueberle F, Zanger U (1988) HEPUS (high energy pulsed ultrasound): apparatus and physical aspects of tumor-insonification. Biomed Tech (Berlin) 33 [Suppl 2]:139–140Google Scholar
  70. 70.
    Riedlinger RE, Brümmer F, Hülser DF (1989) Pulsed high-power-sonication of concrements, cancer cells and rodent-tumors in vivo. Proc Ultrasonics Int 89:305–312Google Scholar
  71. 71.
    Rubin JI, Arger PH, Pollack HM, Banner MP, Coleman BG, Mintz MC, Van Arsdalen KN (1987) Kidney changes after extracorporeal shock wave lithotripsy: CT evaluation. Radiology 162:21–24Google Scholar
  72. 72.
    Russo P, Stephenson RA, Mies C, Huryk R, Heston WDW, Melamed MR, Fair WR (1986) High energy shock waves suppress tumor growth in vitro and in vivo. J Urol 135:626–628Google Scholar
  73. 73.
    Russo P, Mies C, Huryk R, Heston WDW, Fair WR (1987) Histopathologic and ultrastructural correlates of tumor growth suppression by high energy shock waves. J Urol 137:338–341Google Scholar
  74. 74.
    Saitoh T, Ioritani N, Kuwahara M, Shirai S, Kambe K, Taguchi K, Orikasa S (1989) Chronic changes of renal tissue exposed to focused shock waves. Abstract P11-15, 7th World Congress on Endourology and ESWL, Kyoto, 27.–30. 11. 1989Google Scholar
  75. 75.
    Schneider HT, Ell C (1989) Schmerzreaktion: Systemvergleich. Oral presentation, Meeting on Medical Technology, Berlin, 6.–11. 11. 1989Google Scholar
  76. 76.
    Schulze H, Falkenberg F, Mondorf AW, Engelmann U, Senge Th (1988) Enhanced excretion of kidney-derived antigens in the urine of patients after ESWL treatment (abstract). J Urol 139:323Google Scholar
  77. 77.
    Steele R (1988) Blood pressure changes following ESWL. Abstract 0-12, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988Google Scholar
  78. 78.
    Steinmann J, Wilbert DM, Strohmeier WL, Flüchter SH, Bichler KH (1988) Glomerular and tubular changes after extracorporeal shock wave lithotripsy measured by urinary proteins. Abstract 0-9, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988Google Scholar
  79. 79.
    Stephenson TJ, Johnson AG, Ross B (1989) Short-term effects of extracorporeal shock wave lithotripsy on the human gallbladder. J Pathol 158:239–246Google Scholar
  80. 80.
    Sutherland RM (1988) Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240:177–184Google Scholar
  81. 81.
    Tashiro K, Mochizuki A, Machida T (1988) Renal tissues damaged by piezoelectric shock waves. Abstract 0-55, 6th World Congress on endourology and ESWL, Paris, 1.–3. 9., 1988Google Scholar
  82. 82.
    Thomas R, Sloane B, Roberts J (1988) Long-term effect of extracorporeal shock wave lithotripsy on renal function. Abstract 0-11, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9., 1988Google Scholar
  83. 83.
    Tiselius HG, Eriksson I, Sandvall K (1989) Is blood pressure affected by ESWL-treatment? Abstract 05-5, 7th World Congress on Endourology and ESWL, Kyoto, 27–30. 11. 1989Google Scholar
  84. 84.
    Van Dongen JW, Van Steenbrugge GJ, Romijn JC, Schröder FH (1989) The cytocidal effect of high energy shock waves on human prostatic tumour cell lines. Eur J Cancer Clin Oncol 25:1173–1179Google Scholar
  85. 85.
    Weiss N (1989) Verstärkung der Zytostatika-Wirkung durch Stoßwellen. Oral presentation, Körber-Stiftung Symposiuml “Stoßwellen-Anwendungen in der Medizin”, München, 16. 2. 1989Google Scholar
  86. 86.
    Williams AR, Delius M, Miller DL, Schwarze W (1989) Investigation of cavitation in flowing media by lithotripter shock waves both in vitro and in vivo. Ultrasound Med Biol 15:53–60Google Scholar
  87. 87.
    Williams CM, Kaude JV, Newman RC, Peterson JC, Thomas WC (1988) Extracorporeal shock-wave lithotripsy: long-term complications. AJR 150:311–315Google Scholar
  88. 88.
    Wilmer A, Gambihler S, Delius M, Brendel W (1989) In vitro cytotoxic activity of lithotripter shock waves combined with Adriamycin or with cisplatin on L1210 mouse leukemia cells. J Cancer Res Clin Oncol 115:229–234Google Scholar
  89. 89.
    Yang C, Heston WDW, Gulati S, Fair WR (1988) The effect of high energy shock waves (HESW) on human bone marrow. Urol Res 16:427–429Google Scholar
  90. 90.
    Yeaman LD, McCullough DL, Jerome CP (1988) Effects of extracorporeal shock waves on immature bone growth of the rat (abstract). J Urol 139:324Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • F. Brümmer
    • 1
  • Th. Bräuner
    • 1
  • D. F. Hülser
    • 1
  1. 1.Abteilung Biophysik, Biologisches InstitutUniversität StuttgartStuttgart 80Federal Republic of Germany

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