, Volume 3, Issue 1, pp 565–572 | Cite as

A new alloantigen expressed selectively on B cells: the Lyb-2 system

  • Hidetoshi Sato
  • Edward A. Boyse


The new alloantigenic system of the mouse -Lyb-2-is described, and the strain distribution of the phenotype Lyb-2.1 recorded. So far no antiserum to the alternative Lyb-2.2 or other phenotypes is available. On present evidence, the cell-surface component represented by Lyb-2.1 antigen is expressed only on cells of the B-lymphocyte lineage. Cytotoxicity titers of Lyb-2.1 antisera may exceed 1:640 against spleen cells, with maximal lysis usually around 1:80. In two Lyb-2.1+ mouse sublines — CBA/J and C3Hf/Bi — the proportion of spleen cells lysed is lower than in other Lyb-2.1+ strains. The position of theLyb-2 locus has not been found, but close linkage with several loci has been excluded.


Spleen Cell Strain Distribution Close Linkage Present Evidence Maximal Lysis 
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Copyright information

© Springer-Verlag New York Inc. 1976

Authors and Affiliations

  • Hidetoshi Sato
    • 1
  • Edward A. Boyse
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew York

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