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Immunogenetics

, Volume 3, Issue 1, pp 565–572 | Cite as

A new alloantigen expressed selectively on B cells: the Lyb-2 system

  • Hidetoshi Sato
  • Edward A. Boyse
Article

Abstract

The new alloantigenic system of the mouse -Lyb-2-is described, and the strain distribution of the phenotype Lyb-2.1 recorded. So far no antiserum to the alternative Lyb-2.2 or other phenotypes is available. On present evidence, the cell-surface component represented by Lyb-2.1 antigen is expressed only on cells of the B-lymphocyte lineage. Cytotoxicity titers of Lyb-2.1 antisera may exceed 1:640 against spleen cells, with maximal lysis usually around 1:80. In two Lyb-2.1+ mouse sublines — CBA/J and C3Hf/Bi — the proportion of spleen cells lysed is lower than in other Lyb-2.1+ strains. The position of theLyb-2 locus has not been found, but close linkage with several loci has been excluded.

Keywords

Spleen Cell Strain Distribution Close Linkage Present Evidence Maximal Lysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1976

Authors and Affiliations

  • Hidetoshi Sato
    • 1
  • Edward A. Boyse
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew York

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