Abstract
A homozygous antigen-loss variant for the TL antigen was isolated by immunoselectionin vitro. The variant expressed <0.01 the parental amount of TL antigen on its surface as measured by quantitative absorption. Neither theK nor theD end H-2k antigens were detectable on the surface of the variant, although parental amounts of Thy 1.2 and GCSA were expressed. Karyotypic analysis showed that the variant had one less chromosome than the parental line.
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Hyman, R., Stallings, V. Characterization of a TL−variant of a homozygous TL+ mouse lymphoma. Immunogenetics 3, 75–84 (1976). https://doi.org/10.1007/BF01576940
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DOI: https://doi.org/10.1007/BF01576940