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Journal of Industrial Microbiology

, Volume 17, Issue 5–6, pp 417–423 | Cite as

Taxol from fungal endophytes and the issue of biodiversity

  • GA Strobel
  • WM Hess
  • E. Ford
  • RS Sidhu
  • X Yang
Article

Abstract

Fungi represent one of the most understudied and diverse group of organisms. Commonly, these organisms make associations with higher life forms and may proceed to biochemically mimic the host organism. An excellent example of this is the anticancer drug, taxol, which had been previously supposed to occur only in the plant genusTaxus (yew). However, taxol has been reported in a novel endophytic fungus—Taxomyces andreanae, but also has been demonstrated to occur in a number of unrelated fungal endophytes includingPestalotia, Pestalotiopsis, Fusarium, Alternaria, Pithomyces, Monochaetia and others. Thus, this report presents information on the presence of taxol among disparate fungal genera, and uses these observations as an additional argument to support efforts to study fungal endophytes and preserve their associated host plants.

Keywords

fungi mycology taxol Taxus 

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References

  1. 1.
    Cardellina JH. 1991: HPLC separation of taxol and cephalomannine. J Liquid Chromat 14: 659–665.Google Scholar
  2. 2.
    Carroll G. 1990. Fungal endophytes in vascular plants: mycological research opportunities in Japan. Trans Mycol Soc Japan 31: 103–116.Google Scholar
  3. 3.
    Carroll G. 1991. Fungal associates of woody plants as insect antagonists in leaves and stems. In: Microbial Mediation of Plant Herbivore Interactions (Barbosa P and VA Krischik, eds), pp 253–271, John Wiley & Sons, New York.Google Scholar
  4. 4.
    Central Bureau VoorSchimmel Cultures. 1990. List of Cultures. Baarn, Netherlands.Google Scholar
  5. 5.
    Davis EW. 1995. Ethnobotany: an old practice, a new discipline. In: Ethnobotany (Schultes RE and S von Reis, eds), pp 40–51, Discorides Press, Portland, Oregon.Google Scholar
  6. 6.
    Goodman RN, Z Kiraly and KR Wood. 1986. The Biochemistry and Physiology of Plant Disease. p 433. University of Missouri Press, Columbia, MO.Google Scholar
  7. 7.
    Grothaus PG, TJG Raybould, GS Bignami, CB Lazo and JB Bymes. 1993. An enzyme immunosassay for the determination of taxol and taxanes inTaxus sp tissues and human plasma. J Immunol Meth 158: 5–15.Google Scholar
  8. 8.
    Han KH, P Fleming, K Walker, M Loper, WS Chulton, U Mocek, MP Gordon and HG Floss. 1994. Genetic transformation of mature Taxus: an approach to genetically control thein vitro production of the anticancer drug, taxol. Plant Sci 95: 187–196.Google Scholar
  9. 9.
    Hartzel H. 1991. The Yew Tree. Hugolosi Press, Eugene, Oregon.Google Scholar
  10. 10.
    Hawksworth DL. 1991. The fungal dimensiion of biodiversity: magnitude, significance and conservation Mycol Res 95: 641–655.Google Scholar
  11. 11.
    Lee J, E Lobkovsky, NB Pliam, G Strobel and J Clardy. 1995. The subglutinols A & B: immunosuppressive compounds from the endophytic fungus—Fusarium subglutinans. J Org Chem 60: 7076–7077.Google Scholar
  12. 12.
    Li J, G Strobel, R Sidhu, WM Hess and EJ Ford. 1996. Endophytic taxol producing fungi from bald cypressTaxodium distichum. Microbiology (in press).Google Scholar
  13. 13.
    Li XY. 1993. Anti-inflammatory and immunosuppressiveccomponents ofTripterygium wilfordii Int J Immunother 9: 181–187.Google Scholar
  14. 14.
    McClure TD, KH Schram and MLJ Reimer. 1992. The mass spectrometry of taxol. J Am Soc Mass Spectrom 3: 672–679.Google Scholar
  15. 15.
    Nelson TA, T Tousson and WFO Marasas. 1983. Fusarium Species. Pennsylvania State University Press, University Park, Pennsylvania.Google Scholar
  16. 16.
    Stierle A, D Stierle, G Strobel, G Bignami and P Gothaus. 1994. Taxane anticancer agents (Georg GI, TT Chen, I Ojima and DM Vyas, eds: Am Chem Soc Symp Series, Washington, DC). Basic Sci Current Stat 583: 81–97.Google Scholar
  17. 17.
    Stierle A, G Strobel and D Stierle. 1993. Taxol and taxane production byTaxomyces andreanae, an endophytic fungus of Pacific yew. Science 260: 214–216.PubMedGoogle Scholar
  18. 18.
    Strobel GA, X Yang, J Sears, R Sidhu and WM Hess. 1996. Taxol fromPestalotiopsis microspora, an endophytic fungus ofTaxus wallachiana. Microbiology 142: 435–440.PubMedGoogle Scholar
  19. 19.
    Upadhyay RK, GA Strobel and WM Hess. 1991. Morphogenesis and ultrastructure of the conidiomata ofAscochyta cypericold. Mycol Res 95: 785–791.Google Scholar
  20. 20.
    Wani MC, HL Taylor, ME Wall, P Coggen and AT McPhail. 1971. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent fromTaxus brevifolia. J Am Chem Soc 93: 2325–2327.PubMedGoogle Scholar
  21. 21.
    Young DH, EL Michelotti, CS Swindell and NE Krauss. 1992. Antifungal properties of taxol and various analogues. Experientia 48: 882–885.PubMedGoogle Scholar

Copyright information

© Society for Industrial Microbiology 1996

Authors and Affiliations

  • GA Strobel
    • 1
  • WM Hess
    • 2
  • E. Ford
    • 1
  • RS Sidhu
    • 3
  • X Yang
    • 4
  1. 1.Department of Plant PathologyMontana State UniversityBozemanUSA
  2. 2.Department of Botany and Range ScienceBrigham Young UniversityProvo
  3. 3.Cytoclonal Pharmaceutics, IncDallas
  4. 4.Department of Chemistry and BiochemistryConcordia UniversityMontrealCanada

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