Journal of Industrial Microbiology

, Volume 17, Issue 5–6, pp 397–401 | Cite as

Occurrence of cyclosporins and cyclosporin-like peptolides in fungi

  • R Traber
  • M M Dreyfuss
Article

Abstract

Apart from 17 previously listed fungal taxa producing cyclosporin A and its natural congeners B to Z, several additional and taxonomically diverse strains producing the single novel component [Thr2, Leu5, Leu10]cyclosporin or cyclosporin-like peptolides (eg SDZ 214-103=[Thr2, Leu5, D-Hiv8, Leu10]cyclosporin) have recently been described. We report here the isolation of two further and novel cyclosporins, [Thr2, Leu5, Ala10]cyclosporin (2) and [Thr2, Ile5] cyclosporin (3), from strains classified asAcremonium luzulae (Fuckel) W Gams andLeptostroma anamorph ofHypoderma eucalyptii Cooke & Harkn, respectively. In both new strains the usual pattern of cyclosporins A to Z is not found. The structure elucidations of2 and3 are based on NMR spectroscopy, and biological data (immunosuppressive activity, cyclophilin-binding affinity and antifungal effects) are presented.

Keywords

cyclosporins cyclosporin-like peptolides fungal taxa Acremonium luzulae Leptostroma anamorph ofHypoderma eucalyptii 

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Copyright information

© Society for Industrial Microbiology 1996

Authors and Affiliations

  • R Traber
    • 1
  • M M Dreyfuss
    • 1
  1. 1.Preclinical ResearchSandoz Pharma LtdBaselSwitzerland

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