Immunogenetics

, Volume 2, Issue 1, pp 53–61 | Cite as

Genetic control of “natural” killer lymphocytes in the mouse

  • Gyözö G. Petrányi
  • Rolf Kiessling
  • George Klein
Article
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Abstract

Spleens from normal young mice contain lymphocytes that can kill certain in vitro grown Moloney lymphoma lines in a51Cr-release cytotoxicity test. A lymphoid cell without detectable T- or B-cell markers was previously shown to be responsible. Killing activity shows a marked dependence on the genotype of the donor mouse. When tested against a YAC line of strain A origin maintained in vitro spleens of A, A.CA, and A.SW mice had low activity, whereas CBA, C3H, C57L, and C57Bl spleens were highly active. In semisyngeneic F1 crosses with strain A as one parent, reactivity resembled the opposite parental strain. Thus, (A×CBA)F1, (A×C3H)F1, (A×C57L)F1, and (A×C57Bl)F1 were reactive, whereas A×A.CA showed no significant activity. Analysis of the reactivity in (A×C57Bl)F1×A backcross mice suggests that multiple genes are involved. Preliminary linkage analysis suggests at least oneH-2 linked factor. Another gene appears to be linked to theB (black) locus.

Keywords

Lymphoma Linkage Analysis Significant Activity Parental Strain Multiple Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag New York Inc 1975

Authors and Affiliations

  • Gyözö G. Petrányi
    • 1
  • Rolf Kiessling
    • 1
  • George Klein
    • 1
  1. 1.Department of Tumor BiologyKarolinska InstituteStockholm 60Sweden

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