Aesthetic Plastic Surgery

, Volume 6, Issue 3, pp 153–158 | Cite as

Treatment of keloid scars by combined cryosurgery and intralesional corticosteroids

  • B. Hirshowitz
  • D. Lerner
  • A. R. Moscona


Fifty-eight patients with keloid scars were subjected to combined cryosurgery and intralesional corticosteroid therapy. Complete regression of the scars occurred in 41 patients. In 8 patients the scars improved, and there was no improvement in 9 patients. Keloid scars of the earlobes were the most responsive to treatment.

The possibility of differing biological activity of cryosurgery and corticosteroids complementing each other is postulated, and a combination of their respective actions may offer promise in treatment.

Key words

Cryosurgery Keloid scar Corticosteroids 


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  1. 1.
    Baker, BL, Whitaker WL: Interference of wound healing by local action of adrenocortical steroids. Endocrinology46:544, 1950PubMedGoogle Scholar
  2. 2.
    Cohen IK, Keiser HR, Sjoerdsman A: Collagen synthesis in human keloid and hypertrophic scar. Surg Forum22:488, 1971Google Scholar
  3. 3.
    Cohen IK, Keiser HR: Collagen synthesis in keloid and hypertrophic scar following intralesional use of triamcinolone. Surg Forum24:521, 1973PubMedGoogle Scholar
  4. 4.
    Cohen IK, Diegelman RF, Bryant CP: Alpha-globulin collagenase inhibitors in keloid and hypertrophic scar. Surg Forum27:61, 1976Google Scholar
  5. 5.
    Cohen IK, Diegelman RF: The biology of keloid and hypertrophic scar and the influence of corticosteroids. Clin Plast Surg4:297, 1977PubMedGoogle Scholar
  6. 6.
    Gage AA, Fazeckas G, Riley EE Jr: Freezing injury to large blood vessels in dogs. Surgery61:748, 1967PubMedGoogle Scholar
  7. 7.
    Gill W, Frazer J, Carter DC: Repeated freeze-thaw cycles in cryosurgery. Nature (London)219:410, 1968Google Scholar
  8. 8.
    Griffith SH: Treatment of keloids with triamcinolone acetonide. Plast Reconstr Surg38:202, 1966PubMedGoogle Scholar
  9. 9.
    Hirshowitz B, Lerner D, Moscona R: Combined cryosurgery and intralesional corticosteroid therapy for the treatment of keloids. Transactions of the Seventh International Congress of Plastic & Reconstructive Surgery, Rio De Janeiro. São Paulo: Cartgraf, 1979, pp 165–168Google Scholar
  10. 10.
    Holden HB, Saunders S: Cryosurgery. Its scientific basis and clinical application. Practioner210:543, 1973Google Scholar
  11. 11.
    Ketchum LD, Robinson DW, Masters FW: Follow up on treatment of hypertrophic scars and keloids with triamcinolone. Plast Reconstr Surg48:256, 1971PubMedGoogle Scholar
  12. 12.
    Leopard PJ: Cryosurgery and its application to oral surgery. Br J Oral Surg13:128, 1975PubMedGoogle Scholar
  13. 13.
    Lovelock JE: Haemolysis of human red blood cells by freezing and thawing. Biochem Biophys Acta10:414, 1953PubMedGoogle Scholar
  14. 14.
    Lubritz RR: Recent Advances in Cryosurgery of the skin and tumours of the Head and Neck. Setrag A. Zacarian, editor, Springfield IL: CC Thomas, 1977, p 69Google Scholar
  15. 15.
    Maquire HC: Treatment of keloids with triamcinolone acetonide injected intralesionally. JAMA192:325, 1965PubMedGoogle Scholar
  16. 16.
    Mazur P: Kinetics of water loss from cells at subzero temperatures and the likelihood of intracellular freezing. J Gen Physiol47:347, 1963PubMedGoogle Scholar
  17. 17.
    Merryman HT: Mechanics of freezing in living cells and tissues. Science124:515, 1956PubMedGoogle Scholar
  18. 18.
    Michael JC, Mulliken JB, Hoopes JE: Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenrase and alanine amino-transferase activity in keloids. Plast Reconstr Surg56:660, 1975PubMedGoogle Scholar
  19. 19.
    Myers N, Donovan W: Cryohemorrhoidectomy. An experimental study and clinical appraisal. Am. Surg41:799, 1975PubMedGoogle Scholar
  20. 20.
    Pierce HE: Cryosurgery for hypotrophic scars and keloids. Preliminary report. J Natl Med Assoc66:174, 1974PubMedGoogle Scholar
  21. 21.
    Smith AU: Biological Effects of Freezing and Supercooling. Baltimore: Williams & Wilkins, 1961Google Scholar
  22. 22.
    Wittaker DK: Cryosurgery of the oral mucosa. A study of the mechanisms of tissue damage. Dent Pract22:445, 1972Google Scholar
  23. 23.
    Zacarian SA: Cryosurgery of Tumors of the Skin and Oral Cavity. Springfield IL: CC Thomas, 1973, pp 19, 28, 46, 103.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1982

Authors and Affiliations

  • B. Hirshowitz
    • 1
  • D. Lerner
    • 1
  • A. R. Moscona
    • 1
  1. 1.Department of Plastic SurgeryRambam Medical Center, Technion-Faculty of MedicineHaifaIsrael

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