Journal of Industrial Microbiology

, Volume 13, Issue 4, pp 208–211 | Cite as

Microbial molecular diversity: Past and present Thom Award lecture

  • Julian Davies

Key words

Microbial diversity Secondary metabolites Molecular evolution Research funding 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Anders, E. 1989. Pre-biotic organic matter from comets and asteroids. Nature 342: 255–257.PubMedGoogle Scholar
  2. 2.
    Davies, J. 1990. What are antibiotics? Archaic functions for modern activities. Mol. Microbiol. 4: 1227–1232.PubMedGoogle Scholar
  3. 3.
    Davies, J., U. von Ahsen and R. Schroeder. 1993. Antibiotics and the RNA world: a role for low-molecular-weight effectors in biochemical evolution? In: The RNA World (Gesteland, R.F. and J.F. Atkins. eds), pp. 185–204, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.Google Scholar
  4. 4.
    Ferris, J.P. 1987. Prebiotic synthesis: problems and challenges. In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. LII, pp. 29–35, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.Google Scholar
  5. 5.
    Heineman, J.A. and G.F. Sprague. 1989. Bacterial conjugative plasmids mobilize DNA transfer between bacteria and yeast. Nature 340: 205–209.PubMedGoogle Scholar
  6. 6.
    Kleinkauf, H. and H. von Döhren. 1987. Biosynthesis of peptide antibiotics. Annu. Rev. Microbiol. 41: 259–289.PubMedGoogle Scholar
  7. 7.
    Luo, G., D.W. Niesel, R.A. Shaban, E.A. Grimm and G.R. Klimpel. 1993. Tumor necrosis factor alpha binding to bacteria: evidence for a high-affinity receptor and alteration of bacterial virulence properties. Infect. Immun. 61: 830–835.PubMedGoogle Scholar
  8. 8.
    Schroeder, R., B. Streicher and H. Wank. 1993. Splice-site selection and decoding: are they related? Science 260: 1443–1444.PubMedGoogle Scholar
  9. 9.
    Stevens, A.M., N.B. Shoemaker, L.-Y. Li and A.A. Salyers. 1993. Tetracycline regulation of genes onBacteroides conjugative transposons. J. Bacteriol. 175: 6134–6141.PubMedGoogle Scholar
  10. 10.
    Stouthamer, R., R.F. Luck and W.D. Hamilton. 1990. Antibiotics cause parthenogeneticTrichogramma (Hymenoptera/ Trichogrammatidae) to revert to sex. Proc. Natl Acad Sci. USA 87: 2424–2427.PubMedGoogle Scholar
  11. 11.
    Von Ahsen, U. and H.F. Noller. 1993. Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA. Science 260: 1500–1503.PubMedGoogle Scholar
  12. 12.
    Wank, H., J. Rogers, J. Davies and R. Schroeder. 1994. Peptide antibiotics of the tuberactinomycin family as inhibitors of group I intron RNA splicing. J. Mol. Biol. 236: 1001–1010.PubMedGoogle Scholar
  13. 13.
    Zapp, M.L., S. Stern and M.R. Green. 1993. Small molecules that selectively block RNA binding of HIV-1 rev protein inhibit rev function and viral production. Cell 74: 969–978.PubMedGoogle Scholar
  14. 14.
    Zhang, L., P.J. Murphy, A. Kerr and M.E. Tate. 1993.Agrobacterium conjugation and gene regulation byN-acyl-l-homoserine lactones. Nature 362: 446–450.PubMedGoogle Scholar

Copyright information

© Society for Industrial Microbiology 1994

Authors and Affiliations

  • Julian Davies
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of British ColumbiaVancouverCanada

Personalised recommendations