Journal of Industrial Microbiology

, Volume 2, Issue 4, pp 251–255 | Cite as

Methionine induction of ACV synthetase inCephalosporium acremonium

  • Jin-you Zhang
  • Gerald Banko
  • Saul Wolfe
  • Arnold L. Demain
Original Papers

Summary

Methionine markedly stimulates the biosynthesis of penicillin N and cephalosporin C inCephalosporium acremonium. Examination of intra- and extracellular ACV tripeptide in non-producing mutant N-2 showed that growth in the presence of methionine increased ACV accumulation. Direct measurement of ACV synthetase activity in a cell-free system indicated that the methionine effect was mainly due to induction of this first enzyme of the β-lactam biosynthetic pathway, resulting in a corresponding increase in β-lactam production in both a low-producing strain and a high-producing mutant.

Key words

Methionine effect ACV accumulation β-Lactam production 

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Copyright information

© Society for Industrial Microbiology 1987

Authors and Affiliations

  • Jin-you Zhang
    • 1
  • Gerald Banko
    • 1
  • Saul Wolfe
    • 2
  • Arnold L. Demain
    • 1
  1. 1.Fermentation Microbiology Laboratory, Department of Applied Biological SciencesMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Department of ChemistryQueens UniversityKingstonCanada

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