Current Microbiology

, Volume 11, Issue 2, pp 59–65 | Cite as

Evaluation of microbial testing methods for the mutagenicity of quinoline and its derivatives

  • Aris S. Sideropoulos
  • Susan M. Specht
Article

Abstract

Using the “mutational enhancement” method and the Ames test, the mutagenicity and potential carcinogenicity of quinoline and its derivatives were determined and compared. Quinoline, 8-hydroxyquinoline, 5-hydroxyquinoline, 8-hydroxyquinoline sulfate, 6-nitroquinoline, 8-nitroquinoline, and 3-methylquinoline were mutagenic in the Ames direct plating test on TA 98 and TA 100 with activating system (S-9) from the rat liver. These compounds were not mutagenic in the “mutational enchancement” test onEscherichia coli HCR+ strain. 5,7-Dichloro-8-hydroxyquinoline, isoquinoline, and 2-chloroquinoline were nonmutagenic without or with S-9 in both the Ames and “mutational enhancement” test system. The compounds chloroquine, primaquine diphosphate, quinine hydrobromide, quinine hydrochloride, quinine lactate, quinine urea hydrochloride, quinine ethylcarbonate, quinine dihydrochloride, beta quinine quinine valerate, and quinine glycerophosphate were nonmutagenic with and without S-9 in the Ames test but mutagenic (20–60 μg/ml) in the “mutational enhancement” test method onEscherichia coli HCR+ strains. The observations reported here point out that the Ames test responds negatively to several quinoline derivatives that are positive in the “mutational enchancement” test method.

Keywords

Quinoline Chloroquine Quinine Isoquinoline Glycerophosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Aris S. Sideropoulos
    • 1
  • Susan M. Specht
    • 1
  1. 1.Department of Biological SciencesDuquesne UniversityPittsburghUSA

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