Virulence ofAeromonas species as assessed through mouse lethality studies
- 24 Downloads
The relative virulence of 32Aeromonas isolates, primarily of clinical origin, were evaluated for mouse lethality by intraperitoneal inoculation of 107 CFU into albino mice. Three categories could be distinguished on the basis of this assay, including a highly virulent group (80%–100% mortality), a low to moderate virulence category (20%–60% mortality), and strains that were completely avirulent. Of theA. sobria isolates tested, 82% fell into the highly virulent category (P<0.005), whereasA. hydrophila strains were intermediate in virulence potential, andA. caviae strains studied were avirulent. There was no apparent correlation between highly virulentAeromonas isolates and phenotypes associated with enterotoxigenicity, hemolytic activity, cytotoxin production, or serum resistance; this suggests that a cell surface property may be important in mouse pathogenicity. The results of these studies indicate that mouse lethality assays may be an appropriate model for the study of invasive disease clinically produced byA. sobria andA. hydrophila.
Unable to display preview. Download preview PDF.
- 3.D'Alauro F, Ansinelli R (1978)Aeromonas hydrophila septicemia in a previously healthy man. JAMA 240:1139Google Scholar
- 4.De Figueiredo J, Plumb JA (1977) Virulence of different isolates ofAeromonas hydrophila in channel catfish. Aquaculture 11:349–354Google Scholar
- 7.Janda JM, Brenden R, Bottone EJ (1984) Differential susceptibility to human serum byAeromonas spp. Curr Microbiol 11:325–328Google Scholar
- 10.Kou GH (1972) Studies on the occurrence and biochemical properties of virulent and avirulent strains of freshwater fish pathogen,Aeromonas liquefaciens. J Fish Soc Taiwan 1:8–13Google Scholar
- 11.Lallier R, Mittal KR, Leblanc D, Lalonde G, Olivier G (1981) Rapid methods for the differentiation of virulent and nonvirulentAeromonas hydrophila strains. In: International symposium on fish biologics. Basel: S Karger, pp 119–123Google Scholar
- 12.Popoff M (1984). Genus III:Aeromonas Kluyver and Van Niel 1936. In: Krieg NR, Holt JG (eds) Bergey's manual of systematic bacteriology, vol 1. Baltimore: Williams and Wilkins, pp 545–548Google Scholar
- 13.Scott EG, Russell, CM, Noell KT, Sproul AE (1978)Aeromonas hydrophila sepsis in a previously healthy man. JAMA 239:1742Google Scholar
- 15.Wakabayashi H, Kanai K, Hsu TC, Egusa S (1981) Pathogenic activities ofAeromonas hydrophila biovarhydrophila (Chester) Popoff and Veron, 1976 to fishes. Fish Pathol 15:319–325Google Scholar