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Current Microbiology

, Volume 11, Issue 1, pp 19–22 | Cite as

Composition of sputum from patients with cystic fibrosis

  • J. Priscilla Kilbourn
Article

Abstract

Sputum specimens from patients with cystic fibrosis (c.f. sputum) are colozized by a limited number of bacterial species. Attempts to identify the selective nature of the c.f. sputum indicate that this selectivity may be due to the ionic composition of the c.f. sputum. The ionic composition of c.f. sputum appears to be correlated with the presence in the sputum of calmodulin and/or calcitonin. It is suggested that either an abnormal or increased calmodulin and/or an abnormal or decreased calcitonin is the genetic defect(s) in c.f. patients. This abnormal or increased calmodulin and/or abnormal or decreased calcitonin causes the ionic composition of the c.f. sputum to be a selective environment that allows for the colonization of the c.f. sputum by only a few bacterial species.

Keywords

Cystic Fibrosis Genetic Defect Calcitonin Bacterial Species Ionic Composition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature Cited

  1. 1.
    Becker, K. L., Monaghan, K. G., Silva, O. L. 1980. Immunocytochemical localization of calcitonin in Kulchitsky cells of human lung. Archives of Pathology and Laboratory Medicine104:196–198.PubMedGoogle Scholar
  2. 2.
    Boyce, J. R., Miller, R. V. 1980. Effects of cations on stability of cystic fibrosis associated mucoid pseudomonas. Lancet2:268–269.Google Scholar
  3. 3.
    Burns, M. W., May, J. R. 1968. Bacterial precipitins in serum of patients with cystic fibrosis. Lancet1:270–272.PubMedGoogle Scholar
  4. 4.
    Campbell R. A., Grach, J. L., Buxton, S., Kilbourn, P. 1968. C/F kids make good campers—the congenitally malformed XV. Northwest Medicine67:458–461.PubMedGoogle Scholar
  5. 5.
    Filliat, M., Galabert, C., Chazalette, J. P., Dauplan, A. 1981.Pseudomonas aeruginosa strains and variations of Mg2+ levels in the sputum of patients suffering from different respiratory diseases. Monographs in Pediatrics14:142–145.Google Scholar
  6. 6.
    Gnegy, M. E., Erickson, R. P., Markovac, J. 1981. Increased calmodulin in cultured skin fibroblasts from patients with cystic fibrosis. Biochemical Medicine26:294–298.PubMedGoogle Scholar
  7. 7.
    Hostyn, L., Hruskovic, I. 1976. Cysticka Fibroza A bunky C Stitnej Zalzy, [English summary], Casopis Lekaru ceskych115:930–931.PubMedGoogle Scholar
  8. 8.
    Kilbourn J. P., Grach, J. L., Campbell, R. A. 1968. An atypicalEscherichia coli associated with cystic fibrosis of the pancreas. Journal of Pediatrics73:408–411.PubMedGoogle Scholar
  9. 9.
    Kilbourn, J. P. 1978. Bacterial content and ionic composition of sputum in cystic fibrosis. Lancet1:334.PubMedGoogle Scholar
  10. 10.
    Kilbourn, J. P. 1980. Letter to the editor: bacterial flora and ion content of cystic fibrosis sputum. Pediatric Research14:259–260.PubMedGoogle Scholar
  11. 11.
    Lam, J., Chan, R., Lam, K., Costerton, J. W. 1980. Production of mucoid microcolonies byPseudomonas aeruginosa within infected lungs in cystic fibrosis. Infection and Immunity28:546–556.PubMedGoogle Scholar
  12. 12.
    Lewis, A. E. 1966. Biostatistics. New York: Reinhold.Google Scholar
  13. 13.
    Macone, A. B., Pier, G. B., Pennington, J. E., Matthews, Jr., W. J., Goldmann, D. A. 1981. MucoidEscherichia coli in cystic fibrosis. New England Journal of Medicine304:1445–1449.PubMedGoogle Scholar
  14. 14.
    May, J. R., Herrick, N. C., Thompson, D. 1972. Bacterial infection in cystic fibrosis. Archives of Disease in Childhood47:908–913.PubMedGoogle Scholar
  15. 15.
    Quinton, P. M. 1983. Chloride impermeability in cystic fibrosis. Nature301:421–422.PubMedGoogle Scholar
  16. 16.
    Reynolds, H. Y., Di Sant'Agnese, P. A., Zierdt, C. H. 1976. MucoidPseudomonas aruginosa: a sign of cystic fibrosis in young adults with chronic pulmonary disease? Journal of American Medical Association236:2190–2192.Google Scholar
  17. 17.
    Sorscher, E. J., Breslow, J. L. 1982. Cystic fibrosis: a disorder of calcium-stimulated secretion and transepithelial sodium transport? Lancet1:368–370.PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • J. Priscilla Kilbourn
    • 1
  1. 1.Consulting Clinical and Microbiological Laboratory, Inc.PortlandUSA

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