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Immunogenetics

, Volume 1, Issue 1, pp 195–210 | Cite as

Human migrations and linkage disequilibrium ofHL-A system

  • L. Degos
  • J. Dausset
Review

Abstract

A migration with admixture of genes in two populations inducesHL-A linkage disequilibrium or Δ when gene frequencies in the two populations are dissimilar. Since theHL-A linkage disequilibrium disappears very slowly, this factor could be used to recognize some migrations. In the recent migration of American Negroes, a dilution of Caucasoid disequilibrium is noted. By the presence of Δ values, a study of possible migrations around the world is reported and a brief comparison with other methods of research into population origins is discussed in connection with the European ecosphere: a well-known expansion axis is found from East to West (probably due to the Indo-European migration), which ends with admixture with various local Western European populations. Another expansion of genes is noted from the North of Europe towards the Southwest.

Keywords

Linkage Disequilibrium European Population Gene Frequency Population Origin Human Migration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1974

Authors and Affiliations

  • L. Degos
    • 1
  • J. Dausset
    • 1
  1. 1.Laboratory Inserm U93-F-75475 ParisCentre Hayem-Hôpital Saint-LouisFrance

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