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Archives of Sexual Behavior

, Volume 4, Issue 1, pp 1–8 | Cite as

A neuroendocrine predisposition for homosexuality in men

  • Günter Dörner
  • Wolfgang Rohde
  • Fritz Stahl
  • Lothar Krell
  • Wolf-Günther Masius
Article

Abstract

In male rats, androgen deficiency during a critical hypothalamic organizational period was shown to give rise to a predominantly female-differentiated brain, homosexual behavior, and demonstration of a positive estrogen feedback effect. A positive estrogen feedback effect was also induced in intact homosexual men in contrast to intact heterosexual and bisexual men. Thus in 21 homosexual men an intravenous injection of 20 mg Presomen (Premarin) produced a significant decrease of serum LH levels followed by an increase above initial LH values. In 20 heterosexual and in five bisexual men, by contrast, intravenous estrogen administration, while producing a significant decrease of the serum LH level, was not followed by an increase above the initial LH values. Using a radioimmunoassay, plasma testosterone levels and 24-hr urinary excretions of unconjugated testosterone of adult homosexual men were found to be in the normal range as observed in heterosexual men. This finding suggests that homosexual men possess a predominantly female-differentiated brain which may be activated to homosexual behavior by normal or approximately normal androgen levels in adulthood.

Key words

homosexuality neuroendocrine hypothalamus LH testosterone estrogen heterosexuality 

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References

  1. Arimura, A., and Schally, A. V. (1971). Augmentation of pituitary responsiveness to LH-releasing hormone (LH-RH) by estrogen.Proc. Soc. Exptl. Biol. Med. 136:290–293.Google Scholar
  2. Debeljuk, L., Arimura, A., and Schally, A. V. (1972). Effect of testosterone and estradiol on the LH and FSH release induced by LH-releasing hormone (LH-RH) in intact male rats.Endocrinology 90:1578–1581.PubMedGoogle Scholar
  3. Döcke, F., and Dörner, G. (1965). The mechanism of the induction of ovulation by oestrogens.J. Endocrinol. 33:491–499.PubMedGoogle Scholar
  4. Döcke, F., and Dörner, G. (1966). Tierexperimentelle Untersuchungen zur Ovulationsauslösung mit Gonadotropinen und Östrogenen. 4. Mitt.: Zur neurohormonalen Regulation der Ovulation.Zbl. Gynäkol. 88:273–282.Google Scholar
  5. Dörner, G. (1967). Tierexperimentelle Untersuchungen zur Frage einer hormonalen Pathogenese der Homosexualität.Acta Biol. Med. Germ. 19:569–584.PubMedGoogle Scholar
  6. Dörner, G. (1969). Zur Frage einer neuroendokrinen Pathogenese, Prophylaxe und Therapie angeborener Sexualdeviationen.Deutsch. Med. Wschr. 94:390–396.PubMedGoogle Scholar
  7. Dörner, G. (1972).Sexualhormonabhängige Gehirndifferenzierung und Sexualität (Sex Hormone Dependent Brain Differentiation and Sexuality), VEB Gustav Fischer Verlag, Jena, and Springer-Verlag, Wien/New York.Google Scholar
  8. Dörner, G., and Döcke, F. (1964). Sex-specific reaction of the hypothalamo-hypophysial system of rats.J. Endocrinol. 30:265–266.PubMedGoogle Scholar
  9. Dörner, G., and Staudt, J. (1969). Structural changes in the hypothalamic ventromedial nucleus of the male rat following neonatal castration and androgen treatment.Neuroendocrinology 4:278–281.PubMedGoogle Scholar
  10. Dörner, G., and Staudt, J. (1972). Vergleichende morphologische Untersuchungen der Hypothalamusdifferenzierung bei Ratte und Mensch.Endokrinologie 59:152–155.PubMedGoogle Scholar
  11. Dörner, G., Rohde, W., and Baumgarten, G. (1971). Bestimmung des genetischen Geschlechts des Foeten durch fluoreszenz mikroskopischen Nachweis des Y-Chromosoms in Fruchtwasserzellen.Acta Biol. Med. Germ. 26:1095–1098.PubMedGoogle Scholar
  12. Dörner, G., Rohde, W., and Krell, L. (1972). Auslösung eines positiven Ostrogenfeedback-Effekt bei homosexuellen Männern.Endokrinologie 60:297–301.PubMedGoogle Scholar
  13. Dörner, G., Rohde, W., Baumgarten, G., Herter, U., Halle, H., Gruber, G., Rössner, P., Bergmann, K. H., Götz, F., and Zillmann, R. (1973a). Zur pränatalen Geschlechtsbestimmung in Fruchtwasser und peripheren mütterlichen Blut durch fluoreszenzmikroskopischen Nachweis des Y-Chromosoms.Zbl. Gynäkol. 95:625–634.Google Scholar
  14. Dörner, G., Stahl, F., Rohde, W., Halle, H., Rössner, P., Gruber, D., and Herter, U. (1973b). Radioimmunologische Bestimmung des Testosterongehalts in Fruchtwasser männlicher and weiblicher Feten.Endokrinologie 61:317–320.PubMedGoogle Scholar
  15. Hohlweg, W. (1934). Veränderungen des Hypophysenvorderlappens und des Ovariums nach Behandlung mit grossen Dosen von Follikelhormon.Klin. Wschr. 13:92–95.Google Scholar
  16. Illig, R., Pluznik, S., Bambach, M., and Prader, A. (1975). Studies on the effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in children. In Dörner, G. (ed.),Endocrinology of Sex Johann Ambrosius Barth, Leipzig, in press.Google Scholar
  17. Karsch, F. J., Dierschke, D. J., and Knobil, E. (1973). Sexual differentiation of pituitary function: Apparent difference between primates and rodents.Science 179:484–486.PubMedGoogle Scholar
  18. Kinsey, A. C. (1941). Homosexuality: Criteria for a hormonal explanation of the homosexual.J. Clin. Endocrinol 1:424–428.Google Scholar
  19. Nillius, S. J., and Wiede, L. (1971). Induction of a midcycle-like peak of luteinizing hormone in young women by exogenous oestradiol-17β.J. Obstet. Gynaecol. Brit. Commonw. 78:822–827.Google Scholar
  20. Rohde, W., Dörner, G., Knappe, G., Guntermann, S., Groot-Wassink, K., Zillmann, R., and Zywotteck, D. (1974). Erfahrungen mit einem Radioimmunoassay zur Bestimmung von LH und HCG.Zbl. Gynäkol. 96:321–337.Google Scholar
  21. Stahl, F., Dörner, G., Poppe, I., Rohde, W., Knappe, G., Stober, B., and Raabe, B. (1975). Radioimmunologische Bestimmungen von unkonjugiertem Testosteron im Plasma und Harn.Endokrinologie, in press.Google Scholar
  22. Stearns, E. L., Winter, J. S. D., and Fairman, C. (1973). Positive feedback effect of progestin upon serum gonadotropins in estrogen-primed castrate men.J. Clin. Endocrinol. Metab. 37: 635–638.PubMedGoogle Scholar
  23. Swelheim, T. (1965). The influence of a single high dose of oestradiol benzoate on the ICSH-content in the serum of gonadectomized male and female rats.Acta Endocrinol. (Kbh.) 49:231–238.Google Scholar
  24. Tsai, C. C., and Yen, S. S. C. (1971). Acute effects of intravenous infusion of 17β-estradiol on gonadotropin release in pre- and post-menopausal women.J. Clin. Endocrinol. 32:766–771.Google Scholar
  25. Van de Wiele, R. L., Bogumil, F., Dyrenfurth, I., Ferin, M., Jewelewicz, R., Warren, M., Rizkallah, J., and Mikhail, G. (1970). Mechanisms regulating the menstrual cycle in women.Rec. Progr. Hormone Res. 26:63–95.Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • Günter Dörner
    • 1
  • Wolfgang Rohde
    • 1
  • Fritz Stahl
    • 1
  • Lothar Krell
    • 2
  • Wolf-Günther Masius
    • 2
  1. 1.Institute of Experimental EndocrinologyHumboldt University (Charité)BerlinGerman Democratic Republic
  2. 2.Dermatological ClinicBerlin-BuchGerman Democratic Republic

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