Archives of Sexual Behavior

, Volume 24, Issue 2, pp 109–134 | Cite as

Homosexuality, type 1: An Xq28 phenomenon

  • William J. Turner
Article

Abstract

Despite the absence of phenotypic manifestations in alternating generations characteristic of X-linked disorders, a thesis is presented that a major type of Kinsey grades 5 and 6 male homosexuality is determined by a gene in the Xq28 region. A total of 133 families in 78 kinships of male and female homosexual probands, in addition to 116 families (including those of 40 famous homosexuals) from the literature, revealed an unbalanced secondary sex ratio in the maternal generation of male, but not of female, homosexuals. On the maternal side, in this study, the ratio of all uncles to all aunts of 90 males homosexuals was 132/209, χ2 = 8.52, p = 0.004. On the maternal side for the total of all sources, the ratio of uncles to aunts of male homosexuals was 241/367, χ2 = 13.20; p < 0.0001. The male/female ratio of the total number of maternal sibships bearing homosexuals (310/628: 0.491) was a measure of fetal wastage of the mothers' male sibs: 49%. This ratio was very close to that of the total number of children born to fathers affected with any one of nine Xq28-linked male semilethal conditions (255/508: ratio 0.556); for the difference between the two populations χ2 = 0.859, p = 0.354. The male/female ratio of the total number of children born to female carriers of any one of these same conditions (1,232/1,062: ratio 1.16), χ2 = 13.8 p ≤0.0001, is close to that of the total number of children in homosexual sibships: 511/413, χ2 = 10.4, p = 0.005. Between the number of children born to Xq28 mothers and to those born of mothers of homosexuals χ2 = 0.581, p = 0.446. One may readily surmise that the maternal influence so often related to homosexuality may lie in the mother being a genetic carrier, with traits thereto associated. In this study, 65% of the mothers of homosexuals had no or only one live-born brother. Additional support for a genetic hypothesis is found in the occurrence of multiple instances—almost exclusively among maternal relatives—of infertility, spontaneous abortions, miscarriages, stillbirths, remaining single past age 30, and suicide. Of 109 male and 43 female homosexual index cases in the present series there were 6 instances of brother/sister homosexual sibships. Instances of homosexual parent-to-homosexual child transmission occurred as follows: one father-to-son; one father-to-daughter; one bisexual father-son; one father/mother-to-2 sons; one of mother-to-son, and one of father-to-son and father-to-bisexual daughter. There were 16 instances of presumptive transmissions from heterosexual father-to-homosexual son and 5 of heterosexual father-to-homosexual daughter. A hypothesis is proposed: Homosexuality is due to a gene at Xq28 characterized by (i) elongated cytosine-containing trinucleotide repeats upstream to translation of a gene, (ii) elongated CpG islands upstream of the trinucleotides, and (iii) cytosine methylation of CpG islands and of the cytosine-containing trinucleotides.

Key words

homosexuality sex ratio genetic Xq28 nucleotide repeats methylation pseudoautosomal 

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References

  1. Allen, L. S., and Gorski, R. A. (1992). Sexual orientation and the size of the anterior commissure in the human brain.Proc. Nat. Acad. Sci. U.S. 89: 7199–7201.Google Scholar
  2. American Psychiatric Association. (1987).Diagnostic and Statistical Manual of Mental Disorders. 3rd ed., rev., American Psychiatric Association, Washington, DC.Google Scholar
  3. Anvret, M., Gillberg, C., Wahlstrom, J., Albertson-Wikland, K., and Davies, K. (1988). Infantile autism, fragile (X) (q27.3). An RFLP analysis in an extended Swedish family.Clin Genet. 34: 265–271.PubMedGoogle Scholar
  4. Bailey, J. M., and Pillard, R. C. (1991). A genetic study of male sexual orientation.Arch. Gen. Psychiat. 48: 1089–1096.PubMedGoogle Scholar
  5. Bailey, J. M., Pillard, R. C., Neale, M. C., and Agyei, Y. (1993). Heritable factors influence sexual orientation in women.Arch. Gen. Psychiat. 50: 217–223.PubMedGoogle Scholar
  6. Bakwin, H. (1968). Deviant gender role-behavior in children: Relation to homosexuality.Pediatrics 41: 620–629.PubMedGoogle Scholar
  7. Baron, M. (1993). Genetic linkage and male homosexual orientation.Br. Med. J. 307: 337–338.Google Scholar
  8. Berkey, B. R., Perelman-Hall, T., and Kurdek, L. A. (1990). The multidimensional scale of sexuality.J. Homosex. 19: 67–87.Google Scholar
  9. Bieber, I., Dain, H. J., Dince, P. R., Dreilich, M. G., Grand, H. G., Grundlach, R. H., Kremer, M. W., Rifkin, A. H., Wilburm C. B., and Bieber, T. B. (1962).Homosexuality. A Psychoanalytic Study Basic Books, New York.Google Scholar
  10. Brook, J. D. (1993). Retreat of the triplet repeat?Nature Genet. 3: 279–289.PubMedGoogle Scholar
  11. Buchanan, L. A., Bunkton, K. E., Guselen, C. M., Newton, M. S., Clayton, J. F., Christie, S., and Hastie, N. (1987). Ten families with fragile X syndrome: Linkage relationships with four DNA probes from distal Xq.Hum. Genet. 76: 165–172.PubMedGoogle Scholar
  12. Buhrich, N., Bailey, J. M., and Martin, N. G. (1991). Sexual orientation, sexual identity, and sex-dimorphic behaviors in male twins.Behav. Genet. 21: 75–96.PubMedGoogle Scholar
  13. Byne, W., and Parsons, B. (1993). Human sexual orientation: The biological theories reappraised.Arch. Gen. Psychiat. 50: 228–239.PubMedGoogle Scholar
  14. Byrne, J., Warburton, D., Kline, J., Blanc, W., and Stein, Z. (1985). Morphology of early fetal deaths and their chromosomal characteristics.Teratology 32: 297–315.PubMedGoogle Scholar
  15. Coleman, E. (1991). Toward a synthetic understanding of sexual orientation. In McWhirter, D. P., Sanders, S. A., and Reinisch, J. M. (eds.),Homosexuality/Heterosexuality: Concepts of Sexual Orientation Oxford University Press, Oxford, U.K., pp. 268–281.Google Scholar
  16. Diamond, M. (1965). A critical evaluation of the ontogeny of human sexual behavior.Quart. Rev. Biol. 40: 147–175.PubMedGoogle Scholar
  17. Diamond, M. (1993). Some genetic considerations in the development of sexual orientation. In Haug, M., Whalen, R. E., Aron, C., and Olsen, K. L. (eds.),The Development of Sex Differences and Similarities in Behavior Kluwer Academic Publications, Boston, pp. 291–309.Google Scholar
  18. Dittman, R. W., Kappes, M. E., and Kappes, M. H. (1992). Sexual behavior in adolescent and adult females with congenital adrenal hyperplasia.Psychoneuroendocrinology 17: 153–170.PubMedGoogle Scholar
  19. Dömötöri, J. (1966). Zur Frage der Sexualproportion in Verbindung mit der Untersuchung der Sexualchromatine bei der extrauterine Gravidität.Zentralbl. Gynäkol. 88: 191–193.Google Scholar
  20. Dörner, F. (1988). Neuroendocrine response to estrogen and brain differentiation in heterosexuals, homosexuals, and transsexuals.Arch. Sex. Behav. 17: 57–75.PubMedGoogle Scholar
  21. Dörner, G., Poppe, I., Stahl, F., Kölzsch, J., and Uebelhack, R. (1991). Gene- and environment-dependent neuroendocrine etiogenesis of homosexuality and transsexualism.Exp. Clin. Endocrinol. 98: 141–150.PubMedGoogle Scholar
  22. Dunn, H. G., Renpenning, H., Gerrard, J. W., Miller, J. R., Tabata, T., and Federoff, S. (1963). Mental retardation as a sex-linked defect.Am. J. Mental Deficiency 67: 827–848.Google Scholar
  23. Dynes, W. R., and Johnsson, W. (1990).Encyclopedia of Homosexuality, Garland, New York.Google Scholar
  24. Edwards, A. W. F. (1958). An analysis of Geissler's data on the human sex ratio.Ann. Hum. Genet. 232: 6–15.Google Scholar
  25. Ellis, H. (1936).Studies in the Psychology of Sex. Vol. 2: Sexual Inversion Random House, New York.Google Scholar
  26. Emery, A. E. H., and Dreifuss, F. E. (1966). An unusual type of benign X-linked muscular dystrophy.J. Neurol. Neurosurg. Psychiat. 29: 338–342.PubMedGoogle Scholar
  27. Erwin, K. (1993). Interpreting the evidence: Competing paradigms and the emergence of Lesbian and Gay suicide as a “social fact.”Int. J. Health Services 23: 437–453.Google Scholar
  28. Faderman, L. (1981).Surpassing the Love of Men Morrow, New York.Google Scholar
  29. Fausto-Sterling, A., and Balaban, E. (1993). Genetics and male sexual attraction.Science 261: 1257.PubMedGoogle Scholar
  30. Foster, J. H. (1956).Sex Variant Women in Literature. A Historical and Quantitative Survey Vantage, New York.Google Scholar
  31. Freije, D., Helms, C., Watson, M. S., and Doris-Keller, H. (1992). Identification of second pseudoautosomal region near the Xq and Yq telomeres.Science 258: 1784–1787.PubMedGoogle Scholar
  32. Freund, K., Langevin, R., Satterberg, J., and Steiner, B. (1977). Extension of the gender identity scale for males.Arch. Sex. Behav. 6: 507–519.PubMedGoogle Scholar
  33. Friedman, R. C. (1988).Male Homosexuality: A Contemporary Psychoanalytic Perspective Yale University Press, New Haven, CT.Google Scholar
  34. Fu, H.-Y, Kuhl, D. P. A., Pizzuti, A., Pieretti, M., Sutcliffe, J. S., Richards, S. Verkerk, A. J. M. H., Holden, J. J. A., Fenwick, R. G., Jr., Warren, S. T., Oostra, B. A., Nelson, D. L., and Caskey, C. T. (1991). Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox.Cell 67: 1047–1058.PubMedGoogle Scholar
  35. Futuyma, D. J. (1986).Evolutionary Biology 2nd ed. Sinauer, Sunderland, MA.Google Scholar
  36. Futuyma, D. J., and Risch, S. J. (1984). Sexual orientation, psychobiology, and evolution.J. Homosex. 9: 157–168.Google Scholar
  37. Gardner-Garden, M. and Frommer, M. (1989). CpG islands in vertebrate genomes.J. Mol. Biol. 196: 261–282.Google Scholar
  38. Hamer, D. H., Hu, S., Magnuson, V. L., Hu, N., and Pattatucci, A. M. L. (1993). A linkage between DNA markers on the X chromosome and the male sexual orientation.Science 261: 321–327.PubMedGoogle Scholar
  39. Harley, H. G., Rundle, S. A., MacMillan, J. C., Myring, J. C., Brook, J. D., Crow, S., Reardon, W., Fenton, I., Shaw, D. J., and Harper, P. S. (1993). Size of the unstable CTG repeat sequences in relation to phenotype and parental transmission in myotonic dystrophy.Am. J. Hum. Genet. 52: 1164–1174.PubMedGoogle Scholar
  40. Hart, J., and Richardson, L. (1981).The Theory and Practice of Homosexuality Routledge & Kegan Paul, Boston.Google Scholar
  41. Hassold, T. J. (1986). Chromosome abnormalities in human reproductive wastage.Trends Genet. 2: 105–110.Google Scholar
  42. Henry, G. D. (1941).Sex Variants: A Study of Homosexual Patterns Hoeber, New York.Google Scholar
  43. Hirschfeld, M. (1914).Die Homosexualität des Mannes und des Weibes Louis Marcus Verlagsbuchhandlung, Berlin.Google Scholar
  44. Hirschfeld, M. (1936). Homosexuality. In Robertson, V. (ed.),Encyclopedia Sexualis Dingwell-Roche, New York, pp. 321–334.Google Scholar
  45. Hunt, R. A., and LeMaire, R. (1992). Sex-chromosome pairing: Evidence that the behavior of the pseudoautosomal region differs during male and female meiosis.Am. J. Hum. Genet. 50: 1162–1170.PubMedGoogle Scholar
  46. Hurvich, L. M. (1981).Colour vision Sinauer, Sunderland, MA, pp. 263–269.Google Scholar
  47. Jacobs, P. A., Melville, M., Ratcliffe, S., Keay, A. J., and Syme, J. (1974). A cytogenetic survey of 11,680 newborn infants.Ann. Hum. Genet. 37: 359–376.PubMedGoogle Scholar
  48. Jaeger, W., and Schneider, V. J. (1976). Colour vision deficiencies and hemophilia. In Verriest, G. (ed.),Colour Vision Deficiencies. III. International Symposium, Amsterdam. Modern Problems in Ophthalmology, Vol. 17, pp. 143–146.Google Scholar
  49. Josse, J., Kauer, A. D., and Kernberg, A. (1961). Enzymatic synthesis of deoxyribonucleic acid. VIII. Frequencies of neighbor base sequences in deoxyribonucleic acid.J. Biol. Chem. 236: 864–865.PubMedGoogle Scholar
  50. Kenyon, F. E. (1968). Studies in female homosexuality. IV. Social and psychiatric aspects.Br. J. Psychiat. 114: 1337–1343.Google Scholar
  51. Kinnear, P. R. Smith, B. R., and Copland, D. R. (1976). A family with congenital deutan and tritan defects. In Verriest, G. (ed.),Colour Vision Deficiencies. III. International Symposium, Amsterdam. Modern Problems in Ophthalmology, Vol. 17, pp. 131–134.Google Scholar
  52. Kinsey, A. C., Pomeroy, W. B., and Martin, C. E. (1948).Sexual Behavior in the Human Male W. B. Saunders, Philadelphia, PA.Google Scholar
  53. Kinsey, A. C., Pomeroy, W. B., Martin, C. E. and Gebhardt, P. H. (1953).Sexual Behavior in the Human Female W. B. Saunders, Philadelphia, PA.Google Scholar
  54. Kruyer, H., Milà, M., Glover, G., Carbonell, P., Ballesta, F., and Estivill, X. (1994). Fragile X syndrome and the (CGG)N mutation: Two families with discordant MZ twins.Am. J. Hum Genet. 54: 437–442.PubMedGoogle Scholar
  55. LeVay, S. (1991). A difference in hypothalamic structure between heterosexual and homosexual men.Science 253: 1034–1037.PubMedGoogle Scholar
  56. LeVay, S. (1993)The Sexual Brain MIT Press, Cambridge, MA.Google Scholar
  57. Loesch, D. Z., Huggins, R., Hay, D. A., Gedeon, A. K., Mulley, J. C., and Sutherland, G. R. (1993). Genotype-phenotype relationships in Fragile X syndrome: A family study.Am. J. Hum Genet. 53: 1064–1073.PubMedGoogle Scholar
  58. Macke, J. P., Hu, N., Hu, S., Bailey, J. M., King, Van L., Brown, T., Hamer, D., and Nathans, J. (1993). Sequence variation in the androgen receptor gene is not a common determinant of male sexual orientation.Am. J. Hum. Genet. 53: 844–852.PubMedGoogle Scholar
  59. Marmor, J. (1965). Introduction. In Marmor, J. (ed.),Sexual Inversion: The Multiple Roots of Homosexuality Basic Books, New York, pp. 1–24.Google Scholar
  60. Martensen-Larsen, O. (1957). The family constellation and homosexualism.Acta Genet. Med. Gemellog. 7: 445–446.Google Scholar
  61. McConkie-Rosell, A., Lachiewicz, A. M., Spiridigliozzi, G. A., Tarleton, J., Schoenwald, G., Phelan, M. C., Goonewardena, S., Dong, X., and Brown, W. T. (1993). Evidence that methylation of the FMR-I locus is responsible for sex variable phenotypic expression of the fragile X syndrome.Am. J. Hum. Genet. 53: 800–809.PubMedGoogle Scholar
  62. McKusick, V. (1992).Mendelian Inheritance in Man 10th ed., Johns Hopkins University Press, Baltimore, M.D.Google Scholar
  63. Monk, M. (1986). Methylation and the X chromosome.Bioessays 4: 204–208.PubMedGoogle Scholar
  64. Murphy, E. A. (1979).Probability in Medicine Johns Hopkins University Press, Baltimore, M.D.Google Scholar
  65. Naeye, R. L., Burt, L. S., Wright, B. S., Blanc, W. A., and Tatter, D. (1971). Neonatal mortality, the male disadvantage.Pediatrics 48: 902–907.PubMedGoogle Scholar
  66. Nathans, J., Maumenee, I. H., Zenner, E., Sadowski, B., Sharpe, L. T., Lewis, R. A., Hansen, E., Rosenberg, T., Schwartz, M., Heckenlively, J. R., Traboulsi, E., Klingamen, R., Torben, N., Bech-Hansen, G., LaRoche, R., Murphy, W. H., and Weleber, R. G. (1993). Genetic heterogeneity among Blue-Cone Monochromats.Am. J. Hum. Genet. 53: 987–1000.PubMedGoogle Scholar
  67. Neuhann, T., Kalmus, H., and Jaeger, W. (1976). Ophthalmological findings in the tritans, described by Wright and Kalmus. In Verriest, G. (ed.),Colour Vision Deficiencies. III. International Symposium, Amsterdam. Modern Problems in Ophthalmology, Vol. 17, pp. 135–142.Google Scholar
  68. Nordstrom, A. M., Penttinen, M., and von Koskul, H. (1992). Linkage to Xq28 in family with nonspecific X-linked mental retardation.Hum. Genet. 90: 263–266.PubMedGoogle Scholar
  69. Pembrey, M. E., Winter, R. M., and Davies, K. E. (1985). A premutation that generates a defect crossing over explains the inheritance of fragile X mental retardationAm. J. Med. Genet. 21: 709–721.PubMedGoogle Scholar
  70. Pilgrim, C., and Reisert, I. (1992). Differences between male and female brains: Developmental mechanisms and implications.Horm. Metab. Res. 24: 353–359.PubMedGoogle Scholar
  71. Pillard, R. C. (1990). The Kinsey scale: Is it familial? In McWhirter, D., Sanders, S. A., and Reinisch, J. M. (eds.),Homosexuality/Heterosexuality: Concepts of Sexual Orientation Oxford University Press, Oxford, U.K., pp. 88–100.Google Scholar
  72. Pillard, R. C., Pumadere, J., and Carretta, R. A. (1981). Is homosexuality familial? A review, some data, and a suggestion.Arch. Sex. Behav. 10: 465–475.PubMedGoogle Scholar
  73. Pillard, R. C., and Weinrich, J. D. (1986). Evidence of familial nature of male homosexuality.Arch. Gen. Psychiat. 43: 808–812.PubMedGoogle Scholar
  74. Piltz, J. (1921). Przycznek do nauki o homologicznej dziedzicznosci w przypadkach homoseksualizmu.Przeglad Lekarski 60: 29–31. (Translation available from WJT)Google Scholar
  75. Ramgren, O. (1962). A clinical and medico-socio study of hemophilia in Sweden. Dissertation, University of Stockholm.Acta Med. Stockholm (Suppl. 379).Google Scholar
  76. Reiss, A. L., Freund, L., Abrams, M. T., Boehm, C., and Kazazian, H. (1993) Neurobehavioral effects of the Fragile X premutation in adult women: A controlled study.Am. J. Hum. Genet. 52: 884–894.PubMedGoogle Scholar
  77. Richards, C. S., Watkins, S. C., Hoffman, E. P., Schneider, N. R., Milsark, I. W., Katz, K. S., Cook, J. D., Kunkel, L. M., and Cortada, J. M. (1990). Skewed inactivation in a female MZ twin results in Duchenne muscular dystrophy.Am. J. Hum. Genet. 49: 672–681.Google Scholar
  78. Richards, R. I., and Sutherland, G. R. (1992). Heritable unstable DNA sequences.Nature Genet. 1: 7–9.PubMedGoogle Scholar
  79. Riggins, G. J., Lokey, L. K., Chastain, J. L., Leiner, H. A., Sherman, S. L., Wilkinson, K. D., and Warren, S. L. (1992). Human genes containing polymorphic trinucleotide repeats.Nature Genet. 2: 186–191.PubMedGoogle Scholar
  80. Risch, N., Squires-Wheeler, S., and Keats, B. J. B. (1994). Male sexual orientation and genetic evidence.Science 263: 2063–2064. Response, p. 2065.Google Scholar
  81. Roberts, C. J., and Lowe, C. R. (1975). Where have all the conceptions gone?Lancet 1: 498–499.Google Scholar
  82. Roberts, J. A. F., and Pembrey, M. E. (1985).An Introduction to Medical Genetics 8th ed. Oxford University Press, New York.Google Scholar
  83. Rowse, A. L. (1977).Homosexuals in History Macmillan, New York.Google Scholar
  84. Saghir, M. T., and Robins, E. L. (1973).Male and Female Homosexuality: A Comprehensive Investigation Williams and Wilkins, Baltimore, MD, Chap. 8 and p. 137.Google Scholar
  85. Sapienza, C., Peterson, A. E., Rossant, J., and Ballina, R. (1987). Degree of methylation of transgenes is evident on gamete of origin.Nature 328: 251–254.PubMedGoogle Scholar
  86. Schneider, S. G., Farberow, N. L., and Kruks, G. N. (1989). Suicidal behavior in adolescent and young Gay men.Suicide Life Threat. Behav. 19: 381–394.PubMedGoogle Scholar
  87. Sherman, S. L., Morton, N. E., Jacobs, P. A., and Turner, G. (1984). The maker (X) syndrome: A cytogenetic and genetic analysis.Ann. Hum. Genet. 48: 21–37.PubMedGoogle Scholar
  88. Sherman, S. L., Jacobs, P. A., Morton, N. E., Froster-Iskenius, U., Howard Peebles, P. N., Nielson, K. B., Partington, M. W., Sutherland, G. R., Turner, G., and Watson, M. (1985). Further segregation analysis of the fragile X syndrome with special reference to transmitting males.Hum. Genet. 69: 289–299.PubMedGoogle Scholar
  89. Shively, M. G., Jones, C., and DeCecco, J. P. (1984). Research on sexual orientation: Definitions and methods.J. Homosex. 9: 127–136.Google Scholar
  90. Smart, Y. C., Fraser, I. S., Roberts, T., Clancy, R. L., and Cripps, A. W. (1982). Fertilization and early pregnancy loss in healthy women attempting conception.Clin. Reprod. Fertil. 1: 177–184.PubMedGoogle Scholar
  91. Snow, K., Doud, L. K., Hagerman, R., Pergolizzi, R. G., Estee, S. H., and Thibadeau, S. N. (1993). Analysis of CGG sequence at the FMR-I locus in fragile X families and the general population.Am. J. Hum. Genet. 53: 1217–1228.PubMedGoogle Scholar
  92. Stevenson, A. C., and Bobrow, M. (1967). Determination of sex proportions in man, with consideration of the evidence concerning a contribution from X-linked mutations to intrauterine death.J. Med. Genet. 4: 190–219.Google Scholar
  93. Swaab, D. F., and Hofman, M. A. (1990). An enlarged suprachiasmatic nudeus in homosexual men.Brain Res. 537: 147–148.Google Scholar
  94. Swaab, D. F., and Hofman, M. A., Lucasen, P. D., Purba, J. S., Raadsheer, F. L., and van der Nas, J. A. P. (1993). Functional neuroanatomy and neuropathology of the human hypothalamus.Anat. Embryol. 187: 317–330.PubMedGoogle Scholar
  95. Traupe, H., and Vehring, K.-H. (1994). Unstable pre-mutation may explain mosaic disease expression of Incontinential Pigmenti in males.Am. J. Med. Genet. 49: 397–398.PubMedGoogle Scholar
  96. Turner, W. J. (1994). Comments on discordant MZ twinning in homosexuality:Arch. Sex. Behav. 23: 115–119.PubMedGoogle Scholar
  97. van der Ploeg, L. H. T., and Flavell, R. A. (1980). DNA methylation in the human γδβ-globin locus in erythroid and non-erythroid tissues.Cell 19: 947–958.PubMedGoogle Scholar
  98. Verkerk, A. J. M. H., Pieretti, M., Sutliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, D. S., Victoria, M. F., Zhang, F., Eussen, B. E., van Ommer, G.-J. B., Blonden, L. A. J., Riggins, G. J., Chastain, J. L., Kunst, C. A., Galjaard, H., Caskey, C. T., Nelson, D. L., Oostra, B. A., and Warren, S. T. (1991). Identification of a gene (FMR-I) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in Fragile X syndrome.Cell 65: 905–914.PubMedGoogle Scholar
  99. Vogel, F., and Motulsky, A. G. (1979).Human Genetics: Problems and Approaches Springer-Verlag, New York, pp. 187–182.Google Scholar
  100. von Römer, L. S. A. M. (1906).Die Uranische Familie. Untersuchingen über die Ascendenz der Uranier Verlag von Maas und Van Suchtelen, Leipzig/Amsterdam.Google Scholar
  101. Wafelbakker, F. (1975). Marriages of homosexuals.Br. J. Sex. Med. 2: 18–21.PubMedGoogle Scholar
  102. Went, L. N., and de Vries-de Moi, E. C. (1976). Genetics of colour vision. In Verriest, G. (ed.),Colour Vision Deficiencies. III. International Symposium, Amsterdam. Modern Problems in Ophthalmology, Vol. 17, pp. 96–107.Google Scholar
  103. Whitam, F. L., Diamond, M., and Martin, J. (1993). Homosexual orientation in twins.: A report on 61 pairs and three triplet sets.Arch. Sex. Behav. 22: 187–206.PubMedGoogle Scholar
  104. Wilbur, C. B. (1965). Clinical aspects of female homosexuality. In Marmor, J. (ed.),Sexual Inversion: The Multiple Roots of Homosexuality Basic Books, New York, pp. 268–285.Google Scholar
  105. Wilkie, A. O. M. (1993). Detection of cryptic chromosomal abnormalities in unexplained mental retardation: A general strategy using hypervariable subtelomeric DNA polymorphisms.Am. J. Hum. Genet. 53: 688–701.PubMedGoogle Scholar
  106. Wilson, E. O. (1975).Sociobiology: The New Synthesis Belknap, Cambridge, MA.Google Scholar
  107. Wolf, W. (1925). Erblikeitsuntersuchungen zum Problem der Homosexualität.Arch. Psychiat. (Germany) 73: 1–12.Google Scholar
  108. Yu, S., Mulley, J., Loesch, D., Turner, G., Donnelly, A., Gedeon, A., Hillen, D., Kremer, E., Lynch, M., Pritchard, M., Sutherland, G. R., and Richards, R. I. (1992). Fragile-X syndrome: Unique genetics of the heritable unstable element.Am. J. Hum. Genet. 50: 969–980.Google Scholar

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© Plenum Publishing Corporation 1995

Authors and Affiliations

  • William J. Turner
    • 1
  1. 1.Department of PsychiatryState University of New York at Stony BrookStony BrookUSA

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