Journal of Clinical Immunology

, Volume 16, Issue 4, pp 198–207 | Cite as

Interleukin-10 (IL-10) secretion in systemic lupus erythematosus and rheumatoid arthritis: IL-10-dependent CD4+CD45RO+ T cell-B cell antibody synthesis

  • Mansour Al-Janadi
  • Abdullah Al-Dalaan
  • Suliman Al-Balla
  • Mohammed Al-Humaidi
  • Syed Raziuddin
Original Articles

Abstract

Interleukin-10 (IL-10) is a major immunoregulatory cytokine and has a multitude of immunomodulatory effects in the immune system. In this study, we have examined the secretion andin vitro function of IL-10 in B cell hyperactivity in antibody production in two common autoimmune diseases, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). IL-10 was detectable in serum of all active SLE and serum and synovial fluid samples of all RA patients but in none of the normal controls. B cells and CD4+CD45RO+ “memory” T cells secreted highly enhanced levels of IL-10 in SLE and RA versus normals. Increased IgM and IgG production by B cells-CD4+CD45RO+ T cells in SLE and RA was IL-10 dependent, since neutralization of IL-10 cytokine by anti-IL-10 antibody drastically reduced Ig synthesis in these coculture experiments. B cell hyperactivity in autoantibody production in SLE and RA may be a function of IL-10-dependent CD4+CD45RO+ Th2 cell activation. Therefore, IL-10 may play an important role in highly disturbed immune system and B cell-T cell function in these immune disorders.

Key words

Interleukin-10 CD4+CD45RO+ T cells autoimmunity systemic lupus erythematosus rheumatoid arthritis 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Mansour Al-Janadi
    • 1
  • Abdullah Al-Dalaan
    • 2
  • Suliman Al-Balla
    • 1
  • Mohammed Al-Humaidi
    • 1
  • Syed Raziuddin
    • 2
  1. 1.Department of Internal Medicine (RheumatologyKing Saud University, College of MedicineAbhaSaudi Arabia
  2. 2.Tumor Immunology Unit (MBC 03)King Faisal Specialists Hospital & Research CenterRiyadhSaudi Arabia

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