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Digestive Diseases and Sciences

, Volume 33, Issue 6, pp 741–750 | Cite as

Cytomegalovirus colitis in patients with acquired immunodeficiency syndrome

  • E. Rene
  • C. Marche
  • T. Chevalier
  • C. Rouzioux
  • B. Regnier
  • A. G. Saimot
  • Y. Negesse
  • S. Matheron
  • C. Leport
  • B. Wolff
  • B. Moriniere
  • C. Katlama
  • B. Godeberge
  • B. Vittecoq
  • F. Bricaire
  • C. Brun-Vesinet
  • B. Pangon
  • A. M. Deluol
  • J. P. Coulaud
  • J. Modai
  • J. Frottier
  • J. L. Vilde
  • F. Vachon
  • M. Mignon
  • S. Bonfils
Original Articles

Abstract

Twenty-four AIDS patients, who underwent gastrointestinal evaluation, died from their disease and were autopsied. Seven had Cytomegaloviruscolitis (group I) and 17 did not (group II). Clinical manifestations, digestive lesions, and infections were compared in the two groups. Chronic watery diarrhea was present in all the patients with colitis but was also present in 65% of the patients without colitis. Hematochezia was present only in the group with colitis (one of seven patients) but appeared late in the diarrheal course, due to necrotizing colitis. No other difference were noted between the two groups (mean duration of diarrhea, frequency and nature of the other infections). As for group I specifically,colonic ulcerations due to Cytomegaloviruswere present in all the patients, varying from punctate and superficial erosions to deep ulcerations, with granular and friable intervening mucosa. Severe colonic lesions appeared during the course of Cytomegaloviruscolitis in two patients who developed lethal necrotizing colitis. Finally, the clinical and pathologic features of these seven cases were compared to other reports of Cytomegalovirusinfection of the colon.

Key words

AIDS CMV colitis enteral infection 

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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • E. Rene
    • 1
    • 2
  • C. Marche
    • 1
    • 2
  • T. Chevalier
    • 1
    • 2
  • C. Rouzioux
    • 1
    • 2
  • B. Regnier
    • 1
    • 2
  • A. G. Saimot
    • 1
    • 2
  • Y. Negesse
    • 1
    • 2
  • S. Matheron
    • 1
    • 2
  • C. Leport
    • 1
    • 2
  • B. Wolff
    • 1
    • 2
  • B. Moriniere
    • 1
    • 2
  • C. Katlama
    • 1
    • 2
  • B. Godeberge
    • 1
    • 2
  • B. Vittecoq
    • 1
    • 2
  • F. Bricaire
    • 1
    • 2
  • C. Brun-Vesinet
    • 1
    • 2
  • B. Pangon
    • 1
    • 2
  • A. M. Deluol
    • 1
    • 2
  • J. P. Coulaud
    • 1
    • 2
  • J. Modai
    • 1
    • 2
  • J. Frottier
    • 1
    • 2
  • J. L. Vilde
    • 1
    • 2
  • F. Vachon
    • 1
    • 2
  • M. Mignon
    • 1
    • 2
  • S. Bonfils
    • 1
    • 2
  1. 1.Department of GastroenterologyHôpital BichatParis Cedex 18France
  2. 2.Laboratory of Pathology, Laboratory of Virology, Intensive Care Unit, Department of Infectious Disease, Laboratory of Bacteriology, Laboratory of ParasitologyHôpital Claude-BernardParisFrance

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