Digestive Diseases and Sciences

, Volume 34, Issue 5, pp 754–757 | Cite as

Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation

  • Eran Goldin
  • Fanny Karmeli
  • ZVI Selinger
  • Daniel Rachmilewitz
Original Articles


Substance P content was determined by radioimmunoassay in colonic mucosa from 24 patients with chronic severe constipation, 16 with active ulcerative colitis, and 28 normal controls. In patients with chronic severe constipation, the mean concentration of substance P (19.9±8.2 pg/mg) was significantly lower than in normal subjects (71±18 pg/mg). In patients with ulcerative colitis, colonic substance P concentration in inflamed mucosa (170±46 pg/mg) was significantly higher than its levels in normal subjects. Substance P may therefore have a role in the pathogenesis of clinical conditions associated with diarrhea and constipation.

Key words

substance P ulcerative colitis constipation 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Eran Goldin
    • 1
    • 2
  • Fanny Karmeli
    • 1
    • 2
  • ZVI Selinger
    • 1
    • 2
  • Daniel Rachmilewitz
    • 1
    • 2
  1. 1.Department of Gastroenterology, Hadassah University HospitalHebrew University Hadassah Medical SchoolIsrael
  2. 2.Department of Biological ChemistryThe Hebrew UniversityJerusalem

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